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Updated: May 9, 2026

Induction and Testing of Hypoxia in Cell Culture
Published on: August 12, 2011
HIG2 promotes colorectal cancer progression via hypoxia-dependent and independent pathways
Sun-Hee Kim1, Dingzhi Wang, Yun-Yong Park
1Departments of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, United States.
Abstract:
HIG2 (hypoxia-inducible gene 2) is a biomarker of hypoxia and elevated in several cancers. Here, we show that HIG2 also upregulated HIF-1α expression under hypoxic conditions and enhanced AP-1 expression under normoxic conditions, which affects colorectal cancer cell survival. Importantly, over-expression of HIG2 promoted tumor growth by suppressing apoptosis in a mouse orthotopic model. These results are likely relevant to human disease since we found that the expression of HIG2 is gradually elevated as tumors progress. Collectively, these findings suggest that HIG2 plays an important role in promoting colorectal cancer growth in hypoxia-dependent and independent manners.
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