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Toxicity of manganese metallodrugs toward Danio rerio

Anderson Arndt1, Maria Inês Borella, Breno Pannia Espósito

  • 1Instituto de Química, Universidade de São Paulo, Av. Lineu Prestes 748, São Paulo, Brazil.

Chemosphere
|August 7, 2013
PubMed

Insights

Manganese complexes, like EUK108, can be toxic to aquatic life. Researchers studied manganese metallodrugs' environmental impact, finding lipophilicity, stability, and redox activity contribute to their toxicity in zebrafish brain tissue.

Area of Science:

  • Environmental toxicology
  • Metallodrug chemistry
  • Neuroscience

Background:

  • Manganese is essential but can be neurotoxic.
  • Mn-based metallodrugs are increasingly used in medicine.
  • Environmental manganese discharges pose risks to aquatic organisms.

Purpose of the Study:

  • To investigate the physicochemical properties of Mn-based complexes.
  • To assess the acute toxicity of Mn complexes on adult zebrafish (Danio rerio).
  • To evaluate potential brain tissue damage caused by manganese exposure.

Main Methods:

  • Analysis of physicochemical parameters (lipophilicity, stability, redox activity) of Mn complexes.
  • Acute toxicity testing on adult Danio rerio.
  • Histopathological examination of zebrafish brain tissue.

Main Results:

  • The Mn(III)-salen acetate complex EUK108 demonstrated significant toxicity.
  • Toxicity was correlated with the complex's lipophilicity, stability, and redox activity.
  • Observed effects included damage to brain tissue in exposed zebrafish.

Conclusions:

  • Manganese metallodrugs, exemplified by EUK108, can exert toxic effects on aquatic biota.
  • Physicochemical properties are key determinants of manganese complex toxicity.
  • Environmental risk assessment of Mn-based compounds requires consideration of their inherent chemical characteristics and biological impact.
Keywords:
Danio rerioManganeseMetallodrugToxicity

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