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Updated: May 9, 2026

Mouse Embryonic Development in a Serum-free Whole Embryo Culture System
08:55

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Published on: March 1, 2014

Does culture medium influence offspring birth weight?

Beatriz Carrasco1, Montserrat Boada, Ignacio Rodríguez

  • 1Reproductive Medicine Service, Department of Obstetrics, Gynecology, and Reproduction, Hospital Universitari Quirón Dexeus, Barcelona, Spain.

Fertility and Sterility
|August 7, 2013
PubMed
Summary

Embryo culture media type does not impact neonatal birth weight in assisted reproduction. This study found no significant differences in birth weight z scores for infants conceived via in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) across different culture media.

Keywords:
IVF/ICSIbirth weightembryo culture mediumperinatal outcome

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Published on: March 17, 2015

Area of Science:

  • Reproductive Medicine
  • Embryology
  • Neonatal Health

Background:

  • In vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are common assisted reproductive technologies.
  • The selection of appropriate embryo culture media is crucial for successful implantation and development.
  • Previous research has explored various factors influencing neonatal outcomes, but the specific impact of culture media on birth weight requires further clarification.

Purpose of the Study:

  • To investigate whether the type of culture medium used for human embryos influences neonatal birth weight.
  • To compare birth weight outcomes in singletons born after IVF/ICSI utilizing different commercially available embryo culture media.

Main Methods:

  • A prospective randomized study and a retrospective cohort study were conducted.
  • Patients undergoing IVF/ICSI cycles were included, with embryo culture performed in specific media (Cook, Vitrolife, MediCult).
  • Neonatal birth weight, adjusted for gestational age and gender (z score), was the primary outcome measure.

Main Results:

  • No statistically significant differences in mean birth weight z scores were observed between the different culture media groups in both the prospective and retrospective analyses.
  • The average z scores for newborns across all tested media (Cook, Vitrolife, MediCult) were comparable.

Conclusions:

  • The type of embryo culture medium employed in IVF/ICSI procedures does not appear to be associated with variations in neonatal birth weight.
  • These findings suggest that current commercially available culture media are unlikely to significantly affect the birth weight of singletons born via IVF/ICSI.