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Related Concept Videos

Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Preclinical Development: Overview01:28

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Therapeutic Index01:13

Therapeutic Index

The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...

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Related Experiment Video

Updated: May 9, 2026

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions
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eTACTS: a method for dynamically filtering clinical trial search results.

Riccardo Miotto1, Silis Jiang, Chunhua Weng

  • 1Department of Biomedical Informatics, Columbia University, New York, NY 10032, United States.

Journal of Biomedical Informatics
|August 7, 2013
PubMed
Summary

eTACTS dynamically filters clinical trial search results using eligibility tags, significantly improving trial discovery. This novel framework enhances search efficiency and identifies suitable trials often missed by conventional engines.

Keywords:
Association rulesClinical trialsDynamic information filteringInformation storage and retrievalInteractive information retrievalTag cloud

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Area of Science:

  • Biomedical Informatics
  • Clinical Trial Management
  • Information Retrieval

Background:

  • Information overload hinders effective online clinical trial searching.
  • Existing search engines often fail to surface relevant trials efficiently.

Purpose of the Study:

  • Introduce eTACTS, a novel interactive framework for dynamic clinical trial result filtering.
  • Improve the efficiency and intuitiveness of clinical trial searches.

Main Methods:

  • eTACTS mines eligibility tags from trial criteria for indexing.
  • A tag cloud interface allows users to dynamically filter results.
  • The framework iteratively refines results based on tag selection and co-occurrence.

Main Results:

  • eTACTS reduced over a thousand trials to ten in rapid filtering.
  • The system highlighted non-top-ranked, suitable trials.
  • eTACTS retrieved more suitable trials compared to existing search engines.

Conclusions:

  • eTACTS offers intuitive and efficient clinical trial searching via tag-based filtering.
  • Dynamic eligibility tag clouds can enhance current clinical trial search engines.
  • This feasibility study shows eTACTS's advantages over existing systems.