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Related Experiment Video

Updated: May 9, 2026

Performing Permanent Distal Middle Cerebral with Common Carotid Artery Occlusion in Aged Rats to Study Cortical Ischemia with Sustained Disability

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Published on: February 23, 2016

Surgery-induced behavioral changes in aged rats.

Iris B Hovens¹, Regien G Schoemaker, Eddy A van der Zee

¹Department of Molecular Neurobiology, University of Groningen, Nijenborgh 7, 9747 AG, Groningen, The Netherlands.

Experimental Gerontology

|August 7, 2013

Summary

This summary is machine-generated.

Aging surgery patients show increased behavioral and neuroinflammatory responses. Aged rats exhibited long-term affective changes and heightened microglia activation post-surgery, suggesting a link between inflammation and behavioral outcomes.

Keywords:

AUC Aging BLA BSA CA 3 CA1 CFC Cognition DCX DG DGib EDTA EP IBA-1 IL-6 Inflammation MWM MWM test MWM-T Microglia Mood Morris water maze NRS PFC POCD PVP Postoperative cognitive dysfunction SMA Surgery TX Triton-X Y-maze reversal task Y-maze spatial reference task YM YM-R YM-S area under the curve basolateral amygdala bovine serum albumin contextual fear conditioning test cornu ammonis region 1 cornu ammonis region 3 dentate gyrus dentate gyrus inner blade doublecortin-X elevated plus maze ethylenediaminetetraacetic acid interleukin 6 ionized calcium binding adaptor molecule 1 normal rabbit serum polyvinylpyrrolidone postoperative cognitive dysfunction prefrontal cortex sensory motor area spontaneous alternation in the Y-maze

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Last Updated: May 9, 2026

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A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration

Published on: February 27, 2018

Area of Science:

Neuroscience
Gerontology
Immunology

Background:

Postoperative cognitive and mood impairments are common in elderly patients.
Aging is associated with altered neuroinflammatory and behavioral responses.

Purpose of the Study:

To investigate age-related behavioral and neuroinflammatory changes after surgery.
To explore the mechanisms underlying postoperative behavioral alterations in aged individuals.

Main Methods:

Abdominal surgery was performed on young and aged male rats.
Behavioral testing, immunohistochemistry for microglia activation (IBA-1) and neurogenesis (DCX), and IL-6 measurements were conducted.
Effects of anesthesia and cytokine response were evaluated.

Main Results:

Aged rats showed increased weight loss, plasma IL-6, and microglia activation (IBA-1) post-surgery.
Long-term changes in affective behavior and CA1 hippocampal microgliosis were observed in aged rats.
Surgery did not affect cognition in either age group, but microglia activation correlated with behavioral and learning parameters.

Conclusions:

Aging exacerbates behavioral and neuroinflammatory responses to surgery.
Surgery-induced microgliosis in aged rats is linked to long-term behavioral changes.
These findings suggest a relationship between surgical stress, neuroinflammation, and behavioral outcomes in the elderly.