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Two-photon Imaging of Cellular Dynamics in the Mouse Spinal Cord
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Present and emerging therapies for multiple sclerosis.

Mark S Freedman1

  • 1The Ottawa Hospital, 501 Smyth Rd, Ottawa, ON K1H 8L6, Canada. mfreedman@toh.on.ca

Continuum (Minneapolis, Minn.)
|August 7, 2013
PubMed
Summary
This summary is machine-generated.

New therapies for multiple sclerosis (MS) offer more choices beyond older treatments. This review examines emerging MS treatments, their mechanisms, and efficacy for better patient management.

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Area of Science:

  • Neurology
  • Immunology
  • Pharmacology

Background:

  • Multiple sclerosis (MS) treatment landscape is expanding beyond traditional parenteral immunomodulators and early oral therapies.
  • Physicians now have a wider array of therapeutic options for managing MS.
  • Direct comparison of treatment outcomes is limited to head-to-head studies due to variations in clinical trial designs.

Observation:

  • Several new agents for MS have completed phase 3 trials and are nearing or have received regulatory approval.
  • These emerging therapies exhibit diverse mechanisms of action.
  • The review analyzes the perceived efficacy and safety profiles of these novel MS treatments.

Findings:

  • The review discusses current, recent, and imminent therapeutic agents for multiple sclerosis.
  • It evaluates the mechanisms of action and clinical trial results of newly approved or expected MS drugs.
  • These agents are positioned relative to established treatments for multiple sclerosis.

Implications:

  • While optimal treatment selection for individual patients remains challenging, understanding available options is crucial.
  • A strategic approach to utilizing new and existing MS therapies can maximize benefits.
  • Effective management strategies are essential to minimize harm and control relapsing forms of MS.