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Related Experiment Video

Updated: May 9, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

[Mixed squamous and glandular papilloma].

Hiroshi Yabuki¹, Toshiharu Tabata, Takafumi Sugawara

¹Department of Thoracic Surgery, Tohoku Phermaceutical University Hospital, Sendai, Japan.

Kyobu Geka. the Japanese Journal of Thoracic Surgery

|August 7, 2013

Summary

A 64-year-old man with a history of smoking was diagnosed with a lung tumor. Pathology revealed a mixed squamous and glandular papilloma with early-stage squamous cell carcinoma, treated successfully with surgery.

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Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

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RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma

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Area of Science:

Pulmonology
Oncology
Surgical Pathology

Background:

A 64-year-old male smoker presented with a lung mass detected on chest X-ray.
Elevated tumor markers, including carcinoembryonic antigen (CEA) and squamous cell carcinoma-related antigen (SCC), were noted.

Observation:

Computed tomography (CT) identified a 30 mm tumor in the left S8 lung segment.
Fluorodeoxyglucose positron emission tomography (FDG-PET) showed high standardized uptake value (SUV) accumulation in the tumor, suggesting malignancy.
Bronchoscopy-based cytology raised suspicion for squamous cell carcinoma.

Findings:

Video-assisted thoracic surgery (VATS) left lower lobectomy and lymph node dissection were performed.
Pathological examination revealed a mixed squamous and glandular papilloma with papillary growth.
Atypical squamous cells indicated the presence of squamous cell carcinoma in situ within the papilloma.

Implications:

This case highlights the importance of thorough pathological evaluation for mixed epithelial tumors in the lung.
Early detection and surgical intervention are crucial for managing potentially malignant lesions like this.
Understanding the dual cell components is vital for accurate diagnosis and treatment planning in lung neoplasms.