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A Rodent Model of The Ross Operation: Syngeneic Pulmonary Artery Graft Implantation in A Systemic Position

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[Re-aortic valve operations in children].

Tai Fuchigami¹, Yorikazu Harada

¹Department of Cardiovascular Surgery, Nagano Children's Hospital, Azumino, Japan.

Kyobu Geka. the Japanese Journal of Thoracic Surgery

|August 7, 2013

Summary

This summary is machine-generated.

Mechanical aortic valve replacement (AVR) in children with left ventricular outflow tract obstruction (LVOT) shows excellent long-term survival rates. This surgical approach is recommended as a primary treatment option, though careful monitoring for complications is necessary.

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Area of Science:

Cardiovascular Surgery
Pediatric Cardiology
Biomaterials in Medicine

Background:

Left ventricular outflow tract obstruction (LVOT) in pediatric patients often necessitates surgical intervention.
Aortic valve replacement (AVR) using mechanical valves is a critical treatment option for severe cases.
The long-term efficacy and safety of mechanical AVR, with or without annular enlargement, in children require ongoing evaluation.

Observation:

A cohort of 22 pediatric patients underwent mechanical AVR between 1993 and 2012.
The study tracked cumulative survival rates using the Kaplan-Meier method.
Re-operation rates and reasons were documented, including Konno operations, valve replacement due to thrombus, and somatic growth-related re-operations.

Findings:

Mechanical AVR demonstrated excellent cumulative survival rates of 95% at both 5 and 10 years.
Patients operated on at age 2 years and older achieved a postoperative effective orifice area index (EOAI) greater than 0.85 cm²/m² by age 20.
Ten re-operation cases were noted, highlighting the need for potential future interventions.

Implications:

Mechanical AVR is a highly effective and recommended first-choice surgical treatment for pediatric LVOT obstruction at the authors' institution.
While long-term outcomes are excellent, potential anticoagulation-related complications necessitate vigilant patient monitoring.
Further research may focus on optimizing anticoagulation strategies and long-term valve function in pediatric populations.