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Human parvovirus B19 associated dilated cardiomyopathy

Parul Jain1, Amita Jain, Danish Nasar Khan

  • 1Department of Microbiology, KG Medical University, Lucknow, Uttar Pradesh, India.

BMJ Case Reports
|August 7, 2013
PubMed

Insights

Two children with acute heart dysfunction were diagnosed with parvovirus B19 infection. One recovered spontaneously, while the other improved with heart failure therapy and calcium supplementation.

Area of Science:

  • Pediatric Cardiology
  • Infectious Diseases
  • Virology

Background:

  • Acute left ventricular dysfunction in children can be associated with viral infections.
  • Dilated cardiomyopathy requires prompt diagnosis and management.

Observation:

  • Two pediatric cases of acute left ventricular dysfunction with dilated cardiomyopathy were investigated.
  • Testing included a broad range of cardiotropic viruses and serological assays.

Findings:

  • Both patients tested positive for parvovirus B19 infection.
  • One child recovered fully without specific treatment; the other improved with standard heart failure management and calcium/vitamin D supplementation.
  • Sequence analysis identified parvovirus B19 genotype 3 in both cases, marking the first report from India.

Implications:

  • Parvovirus B19 should be considered in the differential diagnosis of pediatric acute heart dysfunction.
  • Genotype 3 parvovirus B19 is circulating in India and can cause significant cardiac morbidity.
  • Early diagnosis and supportive care are crucial for managing parvovirus B19-associated cardiomyopathy.

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