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Related Concept Videos

Autophagy01:27

Autophagy

Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
Delivery Pathways to the Lysosome01:36

Delivery Pathways to the Lysosome

Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
Autophagic Cell Death01:18

Autophagic Cell Death

Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and pro-apoptotic...
Phagocytosis00:41

Phagocytosis

Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis (“cellular eating”) is one of three major types of endocytosis. Cells use phagocytosis to take in large objects—such as other cells (or their debris), bacteria, and even viruses.
Phagocytosis00:41

Phagocytosis

Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis ("cellular eating") is one of three major types of endocytosis. Cells use phagocytosis to take in large objects, such as other cells (or their debris), bacteria, and even viruses.
The objective of phagocytosis is often destruction. Cells use phagocytosis to eliminate unwelcome visitors, like pathogens (e.g., viruses and bacteria). Many immune system cells, including...
Deep Sea Microbial Ecology01:18

Deep Sea Microbial Ecology

The deep ocean and its underlying sediments represent vast, largely unexplored microbial habitats that extend far beyond the sunlit photic zone. The photic (euphotic) zone typically spans the upper ~100–200 meters of pelagic waters in the open ocean, but its depth varies geographically and seasonally, where sufficient light supports photosynthetic life. Below this lies the deep sea, spanning roughly 1000–6000 meters (bathypelagic to abyssal zones), with deeper hadal trenches extending beyond...

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Related Experiment Video

Updated: May 9, 2026

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy
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Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy

Published on: January 31, 2025

Autophagy at sea.

Sascha Martens1, Tor Erik Rusten, Claudine Kraft

  • 1Max F. Perutz Laboratories; University of Vienna; Campus Vienna Biocenter; Vienna, Austria.

Autophagy
|August 7, 2013
PubMed
Summary
This summary is machine-generated.

This conference explored autophagy, a key cellular process. Researchers discussed its molecular mechanisms, physiological roles, and links to diseases like cancer.

Keywords:
EMBOautophagosomeautophagyconferenceisolation membranekinaseslysosomephagophorequality controlselective autophagy

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The Lactate Dehydrogenase Sequestration Assay — A Simple and Reliable Method to Determine Bulk Autophagic Sequestration Activity in Mammalian Cells
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The Lactate Dehydrogenase Sequestration Assay — A Simple and Reliable Method to Determine Bulk Autophagic Sequestration Activity in Mammalian Cells

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Last Updated: May 9, 2026

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The Lactate Dehydrogenase Sequestration Assay — A Simple and Reliable Method to Determine Bulk Autophagic Sequestration Activity in Mammalian Cells
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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Autophagy is a fundamental cellular process involved in degradation and recycling of cellular components.
  • Understanding the molecular mechanisms of autophagy is crucial for comprehending cellular homeostasis and disease pathogenesis.
  • Dysregulation of autophagy is implicated in various pathologies, including neurodegenerative diseases, cancer, and infectious diseases.

Framework:

  • The 3rd EMBO Conference focused on autophagy, covering its molecular mechanisms, physiological regulation, and pathological implications.
  • Key areas of discussion included autophagosome biogenesis, selective autophagy pathways, and the role of autophagy in disease.
  • The conference provided a platform for global researchers to share cutting-edge findings in the field of autophagy.

Implementation:

  • The conference was held on a sea cruise along the Norwegian coastline, fostering a unique and collaborative environment.
  • Researchers presented diverse studies on the molecular machinery governing autophagosome formation and cargo recognition.
  • Discussions highlighted the physiological relevance of autophagy in development, aging, and stress responses.

Implications:

  • Advances in understanding autophagy mechanisms can lead to novel therapeutic strategies for diseases associated with its dysfunction.
  • The conference underscored the importance of selective autophagy in maintaining cellular quality control and preventing disease.
  • Continued research into autophagy's role in pathology promises to unlock new avenues for treatment and disease management.