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[Clinical evaluation of norfloxacin in children]
1Department of Pediatrics, Mie University.
Insights
Norfloxacin (NFLX) demonstrated high efficacy (93.8%) and eradication rates (92.9%) in children with various infections. This antibiotic was found to be safe and well-tolerated in pediatric patients.
Area of Science:
- Pediatric infectious diseases
- Pharmacology and therapeutics
Background:
- Norfloxacin (NFLX) is a fluoroquinolone antibiotic.
- Pediatric infections require effective and safe treatment options.
Observation:
- A study evaluated norfloxacin in 16 children aged 3-14 years.
- Infections treated included respiratory, urinary, and gastrointestinal tracts.
Findings:
- Norfloxacin showed a high efficacy rate of 93.8%.
- The eradication rate for infections treated with norfloxacin was 92.9%.
- No adverse effects were observed during the study.
Implications:
- Norfloxacin appears to be a safe and effective antibiotic option for pediatric infections.
- Further research may support broader use of norfloxacin in children.
Abstract:
We administered norfloxacin (NFLX) to 16 children aged 3 to 14 year-old at the dose of 5.2 to 17.2 mg/kg/day. We evaluated the efficacy and safety of NFLX in 6 children with respiratory tract infections, 8 urinary tract infections, and 2 gastrointestinal tract infections. Efficacy rate of NFLX was 93.8% and eradicated rate was 92.9%. Any adverse effects were not observed. These results suggested that NFLX could be used safely to the children.