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[Clinical studies on norfloxacin in the field of pediatrics]

T Haruta1, S Kuroki, K Okura

  • 1Department of Pediatrics, Kobe City General Hospital.

The Japanese Journal of Antibiotics
|May 1, 1990
PubMed

Insights

Norfloxacin (NFLX) tablets showed a 90% efficacy rate in treating bacterial infections in children aged 6 and older. The study found no adverse effects, suggesting NFLX is a potentially safe and effective treatment option.

Area of Science:

  • Pediatric Infectious Diseases
  • Pharmacology
  • Clinical Microbiology

Context:

  • Norfloxacin (AM-715) is a new quinolone antibiotic.
  • Bacterial infections are common in pediatric populations.

Purpose:

  • To evaluate the clinical efficacy and safety of norfloxacin tablets in children.
  • To assess the bacteriological eradication rates of norfloxacin.

Summary:

  • Ten pediatric patients with various infections (tonsillitis, pharyngitis, bronchitis, enteritis) received norfloxacin (7.0-14.8 mg/kg) thrice daily for 6-8 days.
  • An overall clinical efficacy rate of 90% was observed (8 excellent, 1 good, 1 fair).
  • Bacteriological eradication was achieved in 66.7% of cases, with no adverse reactions or abnormal laboratory findings.

Impact:

  • Norfloxacin demonstrates potential as a safe and effective treatment for bacterial infections in children aged 6 and older.
  • The study supports the use of this new quinolone in pediatric infectious disease management.

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