Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Traumatic Brain Injury l: Introduction01:28

Traumatic Brain Injury l: Introduction

DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Heritable single-cell gene expression states shape functional variability in innate immune responses.

bioRxiv : the preprint server for biology·2026
Same author

Non-invasive assessment of coronary inflammation improves the diagnostic accuracy of coronary death in post-mortem CT angiography.

Journal of cardiovascular computed tomography·2026
Same author

TRACTION for Greater Surgical Use of Tranexamic Acid.

The New England journal of medicine·2026
Same author

Emergency department pulmonary embolism imaging decisions: chief complaint is not enough.

CJEM·2026
Same author

Tranexamic acid for preventing severe bleeding in caesarean births.

BMJ (Clinical research ed.)·2026
Same author

Demographics, clinical features and outcomes of older patients presenting to an Irish emergency department.

Irish journal of medical science·2026
Same journal

Interventions to prevent or cease electronic cigarette use in children and adolescents.

The Cochrane database of systematic reviews·2026
Same journal

Drugs to improve anaemia, quality of life, and physical function in people with myelodysplastic syndromes (MDS).

The Cochrane database of systematic reviews·2026
Same journal

Interventions for smoking cessation in inpatient psychiatry settings.

The Cochrane database of systematic reviews·2026
Same journal

Mechanical thromboprophylaxis for preventing intradialytic hypotension in people undergoing maintenance haemodialysis.

The Cochrane database of systematic reviews·2026
Same journal

Prognostic models for predicting intensive care unit admission or mortality in critically ill adults not yet been admitted to the intensive care unit.

The Cochrane database of systematic reviews·2026
Same journal

Views and experiences of weight management for people living with mobility‑limiting conditions, intellectual disabilities or severe mental illness: a qualitative evidence synthesis.

The Cochrane database of systematic reviews·2026
See all related articles

Related Experiment Video

Updated: May 9, 2026

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
09:49

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

Published on: January 20, 2023

Mannitol for acute traumatic brain injury.

Abel Wakai1, Aileen McCabe, Ian Roberts

  • 1Emergency Care Research Unit (ECRU), Division of Population Health Sciences (PHS), Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland.

The Cochrane Database of Systematic Reviews
|August 7, 2013
PubMed
Summary
This summary is machine-generated.

Mannitol may improve survival compared to pentobarbital for severe head injury, but could increase mortality versus hypertonic saline. Its use in pre-hospital settings requires more research.

More Related Videos

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
07:21

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury

Published on: May 27, 2022

Electromagnetic Controlled Closed-Head Model of Mild Traumatic Brain Injury in Mice
09:07

Electromagnetic Controlled Closed-Head Model of Mild Traumatic Brain Injury in Mice

Published on: September 28, 2022

Related Experiment Videos

Last Updated: May 9, 2026

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
09:49

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

Published on: January 20, 2023

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
07:21

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury

Published on: May 27, 2022

Electromagnetic Controlled Closed-Head Model of Mild Traumatic Brain Injury in Mice
09:07

Electromagnetic Controlled Closed-Head Model of Mild Traumatic Brain Injury in Mice

Published on: September 28, 2022

Area of Science:

  • Neuroscience
  • Critical Care Medicine
  • Pharmacology

Background:

  • Mannitol is used for acute brain swelling, but its long-term efficacy in severe head injury is uncertain.
  • Prolonged mannitol dosage may lead to increased intracranial pressure due to brain penetration.

Purpose of the Study:

  • To evaluate mannitol therapy regimens for managing intracranial pressure (ICP).
  • To compare mannitol with other ICP-lowering agents.
  • To assess mannitol's effectiveness at different stages post-traumatic brain injury.

Main Methods:

  • Systematic review of randomized controlled trials (RCTs) identified through comprehensive database searches.
  • Inclusion criteria: RCTs of mannitol in acute traumatic brain injury, with comparisons to placebo, different doses, or drugs; exclusion of cross-over trials and late interventions (>8 weeks post-injury).
  • Data extraction and quality assessment focused on allocation concealment; relative risks (RR) and confidence intervals (CI) calculated for mortality.

Main Results:

  • Four RCTs were identified.
  • Mannitol vs. pentobarbital: RR for death = 0.85 (95% CI 0.52 to 1.38).
  • Mannitol vs. hypertonic saline: RR for death = 1.25 (95% CI 0.47 to 3.33).
  • Pre-hospital mannitol vs. placebo: RR for death = 1.75 (95% CI 0.48 to 6.38).

Conclusions:

  • Mannitol may reduce mortality compared to pentobarbital but might increase it versus hypertonic saline.
  • ICP-directed therapy shows a slight survival benefit over standard care.
  • Insufficient data exist on pre-hospital mannitol administration effectiveness.