Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of vertical load and speed on toothbrush stiffness measurements.

JADA foundational science·2026
Same author

Power-dependent single-molecule dynamics of dark quencher blinking in QSY9/Cy3B: Diffusion-binding experiment and theory.

The Journal of chemical physics·2026
Same author

The role of effective mass on semiconductor charge carrier localization as revealed by the split operator method.

The Journal of chemical physics·2025
Same author

Correlating photochemical H<sub>2</sub> production and excited state lifetimes of heterostructured and doped ZnCdS nanoparticles.

Nanoscale·2025
Same author

Charcoal dentifrices: A laboratory study of their safety and efficacy.

American journal of dentistry·2024
Same author

An investigation of quantum dot theranostic probes for prostate and leukemia cancer cells using a CdZnSeS QD-based nanoformulation.

Journal of colloid and interface science·2024

Related Experiment Video

Updated: May 9, 2026

Solubilization and Bio-conjugation of Quantum Dots and Bacterial Toxicity Assays by Growth Curve and Plate Count
13:06

Solubilization and Bio-conjugation of Quantum Dots and Bacterial Toxicity Assays by Growth Curve and Plate Count

Published on: July 11, 2012

Water-solubilization and functionalization of semiconductor quantum dots.

Christina M Tyrakowski1, Adela Isovic, Preston T Snee

  • 1University of Illinois at Chicago, Chicago, IL, USA.

Methods in Molecular Biology (Clifton, N.J.)
|August 7, 2013
PubMed
Summary

Researchers developed methods to make hydrophobic semiconductor quantum dots (QDs) water-soluble and functionalize them for biological imaging and sensing applications.

More Related Videos

Compact Quantum Dots for Single-molecule Imaging
17:14

Compact Quantum Dots for Single-molecule Imaging

Published on: October 9, 2012

Synthesis of Cd-free InP/ZnS Quantum Dots Suitable for Biomedical Applications
10:56

Synthesis of Cd-free InP/ZnS Quantum Dots Suitable for Biomedical Applications

Published on: February 6, 2016

Related Experiment Videos

Last Updated: May 9, 2026

Solubilization and Bio-conjugation of Quantum Dots and Bacterial Toxicity Assays by Growth Curve and Plate Count
13:06

Solubilization and Bio-conjugation of Quantum Dots and Bacterial Toxicity Assays by Growth Curve and Plate Count

Published on: July 11, 2012

Compact Quantum Dots for Single-molecule Imaging
17:14

Compact Quantum Dots for Single-molecule Imaging

Published on: October 9, 2012

Synthesis of Cd-free InP/ZnS Quantum Dots Suitable for Biomedical Applications
10:56

Synthesis of Cd-free InP/ZnS Quantum Dots Suitable for Biomedical Applications

Published on: February 6, 2016

Area of Science:

  • Nanotechnology
  • Biomedical Engineering
  • Materials Science

Background:

  • Semiconductor quantum dots (QDs) are fluorescent nanocrystals with significant potential in biological imaging and sensing.
  • Synthesizing high-quality QDs often involves hydrophobic surfactants, hindering direct use in aqueous environments.
  • Existing methods for aqueous QD dispersion require further functionalization for practical applications.

Purpose of the Study:

  • To describe methods for water-solubilizing hydrophobic semiconductor quantum dots (QDs).
  • To present strategies for functionalizing aqueous QD dispersions with chemical and biological vectors.
  • To overcome challenges in conjugating molecules to QDs in aqueous solutions.

Main Methods:

  • Development of novel water-solubilization techniques for hydrophobic QDs.
  • Exploration of functionalization strategies using chemical and biological vectors.
  • Adaptation of conjugation methods to prevent precipitation and low yields in aqueous media.

Main Results:

  • Successful water-solubilization of hydrophobic semiconductor QDs.
  • Effective functionalization of aqueous QD dispersions with various vectors.
  • Demonstration of improved yields and stability in aqueous conjugation processes.

Conclusions:

  • The described methods enable the use of semiconductor quantum dots in aqueous biological applications.
  • Functionalized QDs offer versatile tools for advanced biological imaging and sensing.
  • This work addresses key limitations in the application of QDs in biological systems.