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Ultrasound-Guided Orthotopic Implantation of Murine Pancreatic Ductal Adenocarcinoma
Published on: November 19, 2019
Macrophages in pancreatic cancer: starting things off on the wrong track
Xavier Deschênes-Simard1, Yusuke Mizukami, Nabeel Bardeesy
1Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA.
Abstract:
Chronic inflammation drives initiation and progression of many malignancies, including pancreatic cancer. In this issue, Liou et al. (2013. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201301001) report that inflammatory macrophages are major players in the earliest stages of pancreatic cancer. They show that paracrine signals from the macrophages activate the nuclear factor κB transcriptional program in normal pancreatic acinar cells, resulting in acinar-ductal metaplasia, a dedifferentiated state that is poised for oncogenic transformation.
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