Cutis laxa: a report of two interesting cases

Area of Science:

• Dermatology
• Genetics
• Connective Tissue Diseases

Background:

• Cutis laxa is a rare group of inherited or acquired connective tissue disorders.
• The acquired form of cutis laxa is exceptionally rare, and its pathogenesis remains largely unknown.
• This condition is characterized by generalized or localized loss of skin elasticity.

Purpose of the Study:

• To report two distinct cases of acquired cutis laxa.
• To investigate the clinical presentation and potential triggers of acquired cutis laxa.
• To evaluate treatment outcomes for different forms of acquired cutis laxa.

Main Methods:

• Case report of two patients diagnosed with acquired cutis laxa.
• Clinical examination and patient history to assess systemic involvement and prior conditions.
• Review of treatment modalities, including reconstructive surgery.

Main Results:

• One patient presented with localized acquired cutis laxa following cutaneous inflammation, successfully treated with surgery.
• The second patient exhibited generalized acquired cutis laxa without preceding illness, for whom no satisfactory treatment was found.
• Neither case involved systemic involvement or a history of drug intake.

Conclusions:

• Acquired cutis laxa can manifest in localized or generalized forms with distinct clinical courses.
• Reconstructive surgery may offer satisfactory outcomes for localized acquired cutis laxa.
• Effective treatment strategies for generalized acquired cutis laxa remain elusive, underscoring the need for further research.