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Related Experiment Video

Updated: May 9, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

Generalist solutions to complex problems: generating practice-based evidence--the example of managing

Joanne Reeve¹, Tom Blakeman, George K Freeman

¹University of Liverpool, B122 Waterhouse Buildings, 1-5 Brownlow St, Liverpool L693GL, UK. joanne.reeve@liv.ac.uk

BMC Family Practice

|August 8, 2013

Summary

Addressing multi-morbidity requires new healthcare models. This study explores generalist practice as a complex intervention, generating practice-based evidence for person-centered care solutions.

Related Experiment Videos

Last Updated: May 9, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

Area of Science:

Healthcare Systems Research
Generalist Practice
Complex Interventions

Background:

Increasing prevalence of multiple long-term conditions (multi-morbidity) presents significant challenges for healthcare systems.
Current healthcare models, focused on single diseases, struggle to manage patients with multi-morbidity effectively.
The concept of multi-morbidity is an artifact of disease-centric healthcare design, suggesting a need for alternative approaches.

Purpose of the Study:

To explore generalist practice as a potential solution for managing multi-morbidity.
To address the gap in evidence required by policymakers for service redesign.
To outline a framework for generating practice-based evidence for generalist care models.

Main Methods:

Recognizing generalist practice as a complex intervention within a complex system.
Utilizing action-research principles to evaluate the impact of generalist care.
Focusing on generating practice-based evidence to inform policy and practice.

Main Results:

Generalist practice, defined as whole-person medicine expertise, is proposed as a key strategy.
A significant gap exists in the evidence base for generalism, hindering its adoption in service redesign.
An action-research approach is outlined to generate practice-based evidence.

Conclusions:

Transforming healthcare systems and evidence generation is crucial for tackling multi-morbidity.
Generalist care offers a promising avenue for person-centered solutions in multi-morbidity management.
This work provides a process for generating practice-based evidence to support generalist solutions.