Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inhaled Medications01:23

Inhaled Medications

Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
Sputum Studies II: Culture and Sensitivity01:20

Sputum Studies II: Culture and Sensitivity

Description
Sputum culture and sensitivity is a medical procedure used to diagnose bacterial infections in the respiratory tract and select the most appropriate antibiotics for treatment. This process involves analyzing sputum samples of thick and opaque secretions produced in the lungs and airways. These samples are collected from patients and then sent to the laboratory for analysis.
The test can identify various pathogens responsible for respiratory infections, including Streptococcus,...
Oral Drug Delivery Systems: Introduction01:23

Oral Drug Delivery Systems: Introduction

Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
Clinically Relevant Drug Product Specifications: Methods of Establishment01:29

Clinically Relevant Drug Product Specifications: Methods of Establishment

Product specifications define the acceptable quality of a pharmaceutical product by ensuring identity, purity, potency, and strength. These specifications serve as benchmarks during development, manufacturing, and post-approval quality control. Clinically relevant specifications are particularly important because they directly relate to a drug's safety and efficacy in clinical use.Dissolution studies are critical biopharmaceutic tools that link in vitro behavior to in vivo performance. They...
Additional Routes of Drug Administration01:18

Additional Routes of Drug Administration

Choosing the appropriate route of drug administration is significantly influenced by two key factors: the therapeutic objectives and the inherent properties of the drug being used.
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
Pulmonary Function Tests01:25

Pulmonary Function Tests

Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enhancing aerosol delivery in asthma and COPD: a comparison of MDI, valved holding chamber, and DPI systems using functional respiratory imaging (FRI).

Scientific reports·2026
Same author

Oscillating Positive Expiratory Pressure (OPEP) Therapy in Bronchiectasis and Chronic Obstructive Pulmonary Disease (COPD): A Narrative Review of Clinical Studies.

Pulmonary therapy·2026
Same author

The Fundamentals of the Analysis of Cascade Impactor Data for the Characterization of Aerodynamic Particle Size Distributions (APSDs) in the Testing of Orally Inhaled Drug Products (OIPs).

AAPS PharmSciTech·2025
Same author

Multi-Participant Blinded Investigation into Internal Losses of Medication in Commercially Available Mixing Inlets: Testing Different Orally Inhaled Product Classes Following Pharmacopeial Methods.

Journal of aerosol medicine and pulmonary drug delivery·2025
Same author

Proposals for Global Harmonization of Regulations for Testing of Spacers and Valved Holding Chambers for Pressurized Metered Dose Inhalers.

AAPS PharmSciTech·2025
Same author

Are the Reference Values for the Provocative Concentration of Methacholine Appropriate for Children?

Journal of aerosol medicine and pulmonary drug delivery·2024

Related Experiment Video

Updated: May 9, 2026

Improved Methodology for Liquid Delivery to the Mouse Lung: Intubation using a Consumer Otoscope
13:50

Improved Methodology for Liquid Delivery to the Mouse Lung: Intubation using a Consumer Otoscope

Published on: June 17, 2025

Improved laboratory test methods for orally inhaled products.

Jolyon P Mitchell1, Mark W Nagel

  • 1Trudell Medical International, London, Ontario, Canada. jmitchell@trudellmed.com

Therapeutic Delivery
|August 8, 2013
PubMed
Summary
This summary is machine-generated.

Current in vitro tests for orally inhaled products (OIPs) do not reliably predict lung deposition. New methods are needed to establish better in vitro-in vivo correlations for OIPs.

More Related Videos

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
07:28

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

Methodology for Sputum Induction and Laboratory Processing
13:28

Methodology for Sputum Induction and Laboratory Processing

Published on: December 17, 2017

Related Experiment Videos

Last Updated: May 9, 2026

Improved Methodology for Liquid Delivery to the Mouse Lung: Intubation using a Consumer Otoscope
13:50

Improved Methodology for Liquid Delivery to the Mouse Lung: Intubation using a Consumer Otoscope

Published on: June 17, 2025

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
07:28

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

Methodology for Sputum Induction and Laboratory Processing
13:28

Methodology for Sputum Induction and Laboratory Processing

Published on: December 17, 2017

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery
  • Inhalation Technology

Background:

  • Pharmacopeial methods for orally inhaled products (OIPs) offer limited insight into clinical performance.
  • Established metrics like fine particle fraction (<5 µm) show poor correlation with in vivo lung deposition.
  • Particle imaging techniques offer potential for bridging in vitro-in vivo data gaps.

Purpose of the Study:

  • To re-evaluate the objectives of laboratory testing for OIPs.
  • To guide the development of clinically relevant in vitro methods for OIP assessment.
  • To foster robust in vitro-in vivo relationships for key inhaled drug classes.

Main Methods:

  • Review and reappraisal of existing pharmacopeial testing approaches for OIPs.
  • Exploration of particle imaging-based techniques as potential surrogates for clinical response.
  • Guidance on developing new laboratory methods for OIP performance evaluation.

Main Results:

  • Existing in vitro methods for OIPs are insufficient for predicting in vivo lung deposition.
  • A need exists for clinically relevant laboratory assessments of OIPs.
  • Particle imaging may aid in linking in vitro and in vivo data.

Conclusions:

  • A critical reassessment of OIP laboratory testing is necessary.
  • Developing clinically appropriate in vitro methods is crucial for OIPs.
  • Establishing strong in vitro-in vivo correlations is the ultimate goal for inhaled drug classes.