Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 9, 2026

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

Directing self-assembly of DNA nanotubes using programmable seeds.

Abdul M Mohammed1, Rebecca Schulman

  • 1Chemical and Biomolecular Engineering and ‡Computer Science, Johns Hopkins University , Baltimore, Maryland 21218, United States.

Nano Letters
|August 8, 2013
PubMed
Summary

Researchers developed a DNA origami seed to precisely control DNA nanotube assembly. This seed accelerates growth and determines nanotube circumference, enabling new possibilities for nanodevices.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A DNA-encoded recipe to direct multistage colloidal assembly.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Molecular concentration field design using closed-form steady-state solutions.

Soft matter·2026
Same author

Hydrogels with Tethered Transcription Circuit Elements for Chemical Communication and Collective Computation.

ACS nano·2025
Same author

Dissecting Rate-Limiting Processes in Biomolecular Condensate Exchange Dynamics.

bioRxiv : the preprint server for biology·2025
Same author

Correction to "Directing Nanoparticle Organization in Response to Diverse Chemical Inputs".

Journal of the American Chemical Society·2025
Same author

Spatial Control over Reactions via Localized Transcription within Membraneless DNA Nanostar Droplets.

Journal of the American Chemical Society·2024

Area of Science:

  • Biochemistry
  • Nanotechnology
  • Materials Science

Background:

  • Precise control over nanostructure formation is crucial for developing advanced self-assembled devices.
  • DNA nanotechnology offers a versatile platform for constructing nanoscale architectures.

Purpose of the Study:

  • To design and implement a DNA origami seed to direct the self-assembly of DNA nanotube structures.
  • To investigate the role of the seed in accelerating nucleation, controlling growth, and determining the circumference of DNA nanotubes.

Main Methods:

  • Design and construction of a DNA origami seed structure.
  • Experimental assembly of DAE-E tile DNA nanotubes using the seed.
  • Computational simulations to predict nanotube growth dynamics.

More Related Videos

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
08:15

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures

Published on: June 26, 2020

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules
09:32

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Published on: April 12, 2019

Related Experiment Videos

Last Updated: May 9, 2026

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
08:15

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures

Published on: June 26, 2020

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules
09:32

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Published on: April 12, 2019

Main Results:

  • The DNA origami seed significantly accelerates the nucleation and growth of DNA nanotubes.
  • The seed effectively controls the circumference of the assembled DNA nanotubes.
  • Simulations indicate a minor residual nucleation barrier during seed-templated growth.

Conclusions:

  • DNA origami seeds provide a powerful tool for controlling DNA nanotube self-assembly.
  • This method enables the precise fabrication of custom-designed nanostructures for potential applications in dynamic and multicomponent devices.