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Updated: May 9, 2026
Elastic Staining on Paraffin-embedded Slides of pT3N0M0 Gastric Cancer Tissue
Published on: May 1, 2019
The distinct expression patterns of claudin-2, -6, and -11 between human gastric neoplasms and adjacent
Zhe Lin1, Xiaowei Zhang, Zhijing Liu
1Department of General Surgery, The Second Hospital of Jilin University, Changchun, Jilin, China.
Background:
Cancers have a multifactorial etiology a part of which is genetic. Recent data indicate that expression of the tight junction claudin proteins is involved in the etiology and progression of cancer.
Methods:
To explore the correlations of the tight junction proteins claudin-2,-6, and -11 in the pathogenesis and clinical behavior of gastric cancer, 40 gastric cancer tissues and 28 samples of non-neoplastic tissues adjacent to the tumors were examined for expression of claudin-2,-6, and -11 by streptavidin-perosidase immunohistochemical staining method.
Results:
The positive expression rates of claudin-2 in gastric cancer tissues and adjacent tissues were 25% and 68% respectively (P<0.001). The positive expression rates of claudin-6 in gastric cancer tissues and adjacent tissues were 55% and 79% respectively (P=0.045<0.05). In contrast, the positive expression rates of claudin-11 in gastric cancer tissues and gastric cancer adjacent tissues were 80% and 46% (P=0.004<0.01). Thus in our study, the expression of claudin-2, and claudin-6 was down regulated in gastric cancer tissue while the expression of claudin-11 was up regulated. Correlations between claudin expression and clinical behavior were not observed.
Conclusion:
Our study provides the first evidence that claudin-2,-6, and -11 protein expression varies between human gastric cancers and adjacent non-neoplastic tissues.
Virtual Slides:
The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/5470513569630744.
