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Related Concept Videos

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Updated: May 9, 2026

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
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Published on: March 17, 2020

Granulocyte transfusion therapy.

Anthony A Marfin1, Thomas H Price2

  • 1Puget Sound Blood Center, Seattle, WA, USA Current Address: HIV Prevention Branch, Division of Global HIV/AIDS, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Journal of Intensive Care Medicine
|August 8, 2013
PubMed
Summary
This summary is machine-generated.

Enhanced granulocyte transfusions, using G-CSF stimulation, increase cell counts for neutropenic patients. While cells circulate and function, definitive clinical benefit for infection clearance or survival requires further study.

Keywords:
G-CSFapheresisbacterial infectionchemotherapyfungal infectiongranulocyte transfusiongranulocytopenianeutropenianeutrophil transfusionstem cell transplantation

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Published on: March 14, 2017

Area of Science:

  • Hematology
  • Infectious Diseases
  • Oncology

Background:

  • Neutropenic patients undergoing chemotherapy or stem cell transplantation face high risks of bacterial and fungal infections.
  • Traditional granulocyte transfusion therapy, though available, yielded unimpressive clinical results and adverse events, leading to its decline.
  • Low doses of transfused granulocytes were suspected as a reason for the limited efficacy of traditional therapy.

Purpose of the Study:

  • To evaluate the efficacy of enhanced granulocyte transfusion therapy in treating infections in severely neutropenic patients.
  • To determine if increased numbers of transfused granulocytes, obtained through donor stimulation, improve clinical outcomes.
  • To assess the safety and functionality of granulocytes collected from stimulated donors.

Main Methods:

  • Stimulating normal granulocyte donors with granulocyte-colony stimulating factor (G-CSF) and corticosteroids.
  • Collecting and transfusing increased numbers of granulocytes (3-4 fold higher) to neutropenic recipients.
  • Monitoring granulocyte circulation, neutrophil counts, and in vitro/in vivo cell function in recipients.

Main Results:

  • Transfused granulocytes were shown to circulate in recipients and maintain normal or near-normal neutrophil counts.
  • Granulocytes from stimulated donors demonstrated normal function in various in vitro and in vivo tests.
  • Daily transfusions were capable of sustaining adequate neutrophil levels in severely neutropenic patients.

Conclusions:

  • Enhanced granulocyte transfusion, using G-CSF stimulated donors, can significantly increase the number of transfused granulocytes.
  • These transfused cells appear functional and can maintain neutrophil counts in neutropenic patients.
  • Definitive clinical benefit regarding survival or infection clearance requires further investigation through ongoing clinical trials.