Effects of ionizing radiation on fixed-ratio escape performance in rats

Adult male rats pressed a lever to terminate scrambled footshock according to a fixed-ratio 20 schedule (FR escape). Separate groups of rats received a single whole-body exposure to 4.5 or 7.5 Gray (Gy) of gamma photon radiation or were sham irradiated. The first postirradiation test session began 5 min after the end of the irradiation. The 4.5 Gy dose failed to produce any significant changes in performance over six weeks of testing after exposure. In contrast, response rates after irradiation with 7.5 Gy were decreased over the first four weeks postexposure. Reductions in response rate were due to both an increase in the latency to the first response of a ratio and to a reduction in running response rate. Performance recovered to preirradiation control levels during weeks 5-6 after exposure to 7.5 Gy. Body weights were decreased dose-dependently to a minimum of 91% of preirradiation control values during the third week after exposure to 7.5 Gy. A significant positive correlation existed for changes in the weekly average response rates and body weights at this dose. When a total dose of 7.5 Gy was delivered as 1.5 Gy per day for five consecutive days (dose fractionation), there were no significant changes in performance over eight weeks of testing although reversible decreases in response rates occurred in three of six rats. By comparison with previous studies these results demonstrate that FR escape performance may provide a more sensitive index of radiation-induced behavioral disruption than performance maintained by several other schedules of negative reinforcement.(ABSTRACT TRUNCATED AT 250 WORDS)