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Uric acid excretion in rotavirus gastro-enteritis

Amar Al-Shibli, Hossam Al Tatari, Abdulla Al Ameri

    Paediatrics and International Child Health
    |August 8, 2013
    PubMed

    Insights

    Rotavirus gastroenteritis (GE) in children does not increase the risk of hyperuricosuria compared to other viral GE causes. This study found no significant differences in uric acid levels or excretion between groups, suggesting further research is needed.

    Area of Science:

    • Pediatric Nephrology
    • Infectious Diseases
    • Urology

    Background:

    • Urate urolithiasis in children has been linked to rotavirus (RV) gastroenteritis (GE) in Japan.
    • Investigating the association between RV GE and hyperuricosuria is crucial for understanding pediatric kidney stone formation.

    Purpose of the Study:

    • To test the hypothesis that children with RV GE have an increased risk of hyperuricosuria compared to those with GE from other viral causes.
    • To analyze urinary uric acid excretion in children with GE.

    Main Methods:

    • Prospective analytic cohort study involving 87 Emirati children with GE.
    • Comparison of serum and urinary uric acid levels, fractional excretion of uric acid (FEur), and uric acid to creatinine clearance between RV GE (Group R) and other viral GE (Group N) cohorts.
    • Analysis included blood urea, creatinine, uric acid, and urinary pH and specific gravity.

    Main Results:

    • No significant differences were observed in blood urea, creatinine, or uric acid levels between Group R and Group N.
    • Urinary uric acid excretion, measured by Uur/Ucr ratio, uric acid for creatinine clearance, and FEur, showed no significant difference between the two groups.
    • Urinary pH and specific gravity were also comparable between children with RV GE and those with other viral GE.

    Conclusions:

    • The study found no significant difference in uric acid levels or excretion in children with rotavirus GE compared to those with other presumed viral causes of GE.
    • Larger sample sizes and studies including children with severe dehydration or prolonged GE are recommended for further investigation.
    Abstract

    Keywords:
    Diarrhoea,Kidney calculi,Urinary calculi,Urolithiasis

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