Related Experiment Video
Updated: May 9, 2026

13:00
The Insect Galleria mellonella as a Powerful Infection Model to Investigate Bacterial Pathogenesis
Published on: December 11, 2012
Necrotizing fasciitis and death following an insect bite
Dinesh Malcolm G Fernando1, Chandishni I Kaluarachchi, Champa N Ratnatunga
1Department of Forensic Medicine, Faculty of Medicine, University of Peradeniya, Kandy, Sri Lanka. dineshmgfdo@yahoo.com
The American Journal of Forensic Medicine and Pathology
|August 8, 2013
Summary
A tick bite led to a fatal case of necrotizing fasciitis caused by Group A Streptococcus. Early recognition and aggressive treatment are crucial for this rare, rapidly progressing infection.
Area of Science:
- Medical Microbiology
- Pathology
- Infectious Diseases
Background:
- Insect bites, particularly from ticks, can rarely lead to severe secondary bacterial infections.
- Necrotizing fasciitis is a rapidly progressive soft tissue infection with high mortality.
- Prompt diagnosis and intervention are critical for managing necrotizing fasciitis.
Observation:
- A healthy male presented with a swollen, painful left arm post-tick bite.
- The patient rapidly progressed to shock and expired within 48 hours.
- Postmortem examination revealed necrotic subcutaneous tissue and skin changes consistent with necrotizing fasciitis.
Findings:
- Group A β-hemolytic Streptococcus was identified as the causative agent from infected tissue.
- Histopathology confirmed necrotizing fasciitis, characterized by subcutaneous necrosis.
- The infection extended below the elbow, involving skin and subcutaneous layers.
Implications:
- Clinicians must maintain a high index of suspicion for necrotizing fasciitis following insect bites.
- Aggressive and timely treatment is essential to prevent fatalities from this rare complication.
- Pathologists and medical professionals should be aware of the potential link between insect bites and severe bacterial infections like necrotizing fasciitis.
Related Concept Videos
Necrosis
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...
Cellular Injury IV: Necrosis
Necrosis is a form of irreversible cell death caused by severe injury such as ischemia, toxins, or trauma. Unlike programmed cell death, it is an uncontrolled, pathological process that typically provokes inflammation in surrounding tissues.Pathophysiologic ChangesNecrosis begins when cells sustain critical damage, leading to swelling of organelles, particularly mitochondria, and rapid ATP depletion. As energy levels decline, membrane ion pumps fail, leading to calcium influx and eventually,...
Arboviral Encephalitis
Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
Bacterial Meningitis I: Introduction
Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Diphtheria
Diphtheria is an acute, toxin-mediated infectious disease that primarily affects the upper respiratory tract. It is caused by Corynebacterium diphtheriae, a Gram-positive, pleomorphic rod that lacks spore-forming capability and exhibits a characteristic club-shaped morphology under microscopic examination. While C. diphtheriae can asymptomatically colonize mucosal surfaces, clinical disease manifests only when the bacterial strain is lysogenized by a specific β-corynephage. This phage...
Bacterial Meningitis II: Pathophysiology
Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...