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Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...

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Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay (EMSA) and DNA-affinity Precipitation Assay (DAPA)
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A controllable susceptibility marker for passive device tracking.

William Dominguez-Viqueira1, Hirad Karimi, Wilfred W Lam

  • 1Imaging Research, Sunnybrook Research Institute, Toronto, Ontario, Canada.

Magnetic Resonance in Medicine
|August 8, 2013
PubMed
Summary
This summary is machine-generated.

A novel MRI tracking device with a switchable artifact was developed. This innovation allows for precise catheter navigation and imaging, minimizing interference during procedures.

Keywords:
endovascularguidinginterventionssusceptibility markerstracking device

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Area of Science:

  • Biomedical Engineering
  • Medical Imaging
  • Materials Science

Background:

  • Accurate tracking of interventional devices is crucial for minimally invasive procedures.
  • Existing tracking methods often suffer from artifact generation, limiting real-time imaging capabilities.
  • The need for passive, on-demand tracking solutions is significant in interventional radiology.

Purpose of the Study:

  • To design and demonstrate a novel susceptibility-based tracking device.
  • The device features a mechanically switchable artifact for on/off functionality.
  • This enables artifact-limited tracking and imaging at the device tip.

Main Methods:

  • Magnetic susceptibilities of titanium and graphite were measured.
  • Numerical optimization determined layer thicknesses for artifact cancellation.
  • A 3 mm outer diameter tracking element was fabricated and attached to a catheter.

Main Results:

  • The device was successfully integrated into a 9F catheter.
  • Catheter navigation through a carotid artery bifurcation was demonstrated under fluoroscopy.
  • MR images with the device in both 'on' and 'off' states were acquired.

Conclusions:

  • A new passive tracking device with a controllable susceptibility effect was successfully designed, fabricated, and demonstrated.
  • The device functions in both phantom and in vivo settings.
  • Potential integration into other interventional MR devices like needles and ultrasound transducers was highlighted.