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Updated: May 9, 2026

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10:15

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Changes in tumour vessel density upon treatment with anti-angiogenic agents: relationship with response and

N S Vasudev1, V Goh, J K Juttla

  • 1Tumour Biology Team, Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.

British Journal of Cancer
|August 8, 2013
PubMed
Abstract

Insights

Tumor enhancement changes correlate with treatment response and resistance in patients receiving anti-angiogenic therapy. Reduced enhancement indicates tumor shrinkage, while rebound vascularization suggests acquired resistance.

Area of Science:

  • Oncology
  • Radiology
  • Pharmacology

Background:

  • Investigating tumor vessel density as a marker for anti-angiogenic therapy response.
  • Assessing correlation between tumor enhancement and treatment outcomes.

Purpose of the Study:

  • To correlate changes in tumor vessel density with response and resistance to anti-angiogenic therapy.
  • To understand mechanisms of response and resistance to tyrosine kinase inhibitors.

Main Methods:

  • Arterial phase contrast-enhanced CT in metastatic renal cancer patients.
  • Simultaneous measurement of tumor size and enhancement (tumor vessel density surrogate).
  • Analysis of individual lesion responses and rebound vascularization.

Main Results:

  • Reduced tumor enhancement strongly correlated with lesion size reduction.
  • Observed diverse responses within individual lesions and across patients.
  • Rebound vascularization amplitude was greater in lesions with better initial response.

Conclusions:

  • Tumor enhancement changes serve as a surrogate marker for anti-angiogenic therapy response and resistance.
  • Provides insights into the mechanisms of action and resistance to anti-angiogenic agents.

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