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The apgar score and infant mortality
Fei Li1, Ting Wu, Xiaoping Lei
1Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Insights
The Apgar score remains valuable for predicting infant survival up to one year, identifying risks in both preterm and term infants, including twins and diverse racial groups.
Area of Science:
- Neonatal and Perinatal Medicine
- Public Health
- Pediatric Mortality Studies
Background:
- The Apgar score, established over 50 years ago, is a standard measure of newborn health at birth.
- Its continued relevance in predicting long-term infant outcomes requires ongoing evaluation.
Purpose of the Study:
- To assess the enduring utility of the Apgar score in current medical practice.
- To determine the Apgar score's predictive power for infant mortality beyond the neonatal period.
Main Methods:
- Analysis of a large U.S. birth dataset (over 25 million singleton and 768,000 twin births).
- Utilized Cox proportional hazard models to link Apgar scores to infant mortality risk within the first year.
- Examined outcomes stratified by gestational age, birth type (singleton/twin), and race/ethnicity.
Main Results:
- Low Apgar scores (1-3) at five minutes were associated with persistently high neonatal and post-neonatal mortality rates, even in term infants.
- High Apgar scores (≥7) correlated with progressively lower mortality rates as gestational age increased.
- Racial disparities in mortality were observed, with non-Hispanic White infants having higher neonatal mortality and Black infants having higher post-neonatal mortality.
- Apgar score's predictive pattern for mortality was consistent across singleton and twin births.
Conclusions:
- The Apgar score retains significant value in predicting adverse neonatal and post-neonatal outcomes.
- Its predictive capability extends to both term and preterm infants, as well as twins and various racial/ethnic populations.
- The Apgar score remains a pertinent tool for risk assessment in contemporary obstetrics and pediatrics.
Objective:
To evaluate if the Apgar score remains pertinent in contemporary practice after more than 50 years of wide use, and to assess the value of the Apgar score in predicting infant survival, expanding from the neonatal to the post-neonatal period.
Methods:
The U.S. linked live birth and infant death dataset was used, which included 25,168,052 singleton births and 768,305 twin births. The outcome of interest was infant death within 1 year after birth. Cox proportional hazard-model was used to estimate risk ratio of infant mortality with different Apgar scores.
Results:
Among births with a very low Apgar score at five minutes (1-3), the neonatal and post-neonatal mortality rates remained high until term (≥ 37 weeks). On the other hand, among births with a high Apgar score (≥7), neonatal and post-neonatal mortality rate decreased progressively with gestational age. Non-Hispanic White had a consistently higher neonatal mortality than non-Hispanic Black in both preterm and term births. However, for post-neonatal mortality, Black had significantly higher rate than White. The pattern of changes in neonatal and post-neonatal mortality by Apgar score in twin births is essentially the same as that in singleton births.
Conclusions:
The Apgar score system has continuing value for predicting neonatal and post-neonatal adverse outcomes in term as well as preterm infants, and is applicable to twins and in various race/ethnic groups.
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