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Related Experiment Video

Updated: May 9, 2026

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

Aberrant default mode functional connectivity in early onset schizophrenia.

Jinsong Tang¹, Yanhui Liao, Ming Song

¹Institute of Mental Health, the Second Xiangya Hospital, Central South University, Changsha, Hunan, PR China.

|August 8, 2013

Summary

This study reveals altered default mode network (DMN) connectivity in early onset schizophrenia (EOS) patients, specifically increased functional connectivity (FC) in the medial frontal gyrus linked to positive symptoms.

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Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network

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Published on: December 28, 2010

Area of Science:

Neuroscience
Psychiatry
Brain Imaging

Background:

The default mode network (DMN) is implicated in various mental disorders.
Abnormal DMN connectivity in early onset schizophrenia (EOS) remains under-investigated.

Purpose of the Study:

To investigate functional connectivity (FC) of the DMN in first-episode EOS patients.
To explore the relationship between DMN FC and symptom severity in EOS.

Main Methods:

Utilized independent component analysis (ICA) to assess DMN FC.
Included 32 first-episode EOS adolescents and 32 age/gender-matched healthy controls.
Employed partial correlation to analyze symptom associations.

Main Results:

EOS patients exhibited increased FC between the medial frontal gyrus and other DMN regions compared to controls.
Medial frontal gyrus FC positively correlated with positive symptoms of schizophrenia (PANSS).

Conclusions:

First-episode EOS is associated with functional DMN abnormalities.
These DMN alterations may contribute to abnormal introspective thought processes in EOS.
Findings highlight potential neural correlates of early-stage schizophrenia symptoms.