Related Experiment Video
Updated: May 9, 2026

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
Published on: November 9, 2016
Assessment and management of paracetamol poisoning in adults
1National Poisons Information Service, Edinburgh. janice.pettie@luht.scot.nhs.uk
Abstract:
Paracetamol is a low cost, effective analgesic that is widely available in the UK. Paracetamol is the drug most commonly taken in overdose and can lead to acute liver failure, which can be fatal. This article focuses on the assessment and management of paracetamol poisoning in adults. It includes current UK guidelines on paracetamol poisoning, which changed in September 2012 following a review by the Commission on Human Medicines. It also discusses strategies to reduce incidence and severity of paracetamol poisoning, and outlines the metabolism of paracetamol at therapeutic doses and in overdose.
Related Concept Videos
Pharmaceutical Poisoning: Treatment Strategies
Prevention of Further Absorption of Poison
Pharmaceutical Poisoning: Potential Scenarios
Anticholinesterase Agents: Poisoning and Treatment
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is slower than the...
Acute Pancreatitis II: Clinical Manifestations and Management
Enhanced Elimination of Poison
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
