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Updated: May 9, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

[New perspectives in cardiovascular risk reduction: focus on HDL]

Stefania Paolillo1, Giuseppe Luca Della Ratta, Alice Vitagliano

  • 1Department of Advanced Biomedical Sciences, Federico II University; Via Pansini 5, I-80131 Naples, Italy.

Monaldi Archives for Chest Disease = Archivio Monaldi Per Le Malattie Del Torace
|August 9, 2013
PubMed

Insights

Cardiovascular diseases are a leading cause of death globally. This review explores how increasing high-density lipoprotein (HDL) levels can help prevent heart disease and reduce cardiovascular risk.

Area of Science:

  • Cardiology and Atherosclerosis Research
  • Lipid Metabolism and Cardiovascular Health

Context:

  • Cardiovascular diseases (CVDs) are the primary global cause of morbidity and mortality.
  • Dyslipidemias are a significant modifiable risk factor for CVDs.
  • Elevated low-density lipoprotein (LDL) and decreased high-density lipoprotein (HDL) levels impact cardiovascular event risk.

Purpose:

  • To review current evidence on the protective effects of HDL lipoproteins.
  • To present recent pharmacological strategies for increasing HDL levels.
  • To highlight methods for reducing cardiovascular risk by modulating HDL concentrations.

Summary:

  • This review synthesizes research on the atheroprotective functions of HDL.
  • It examines lifestyle modifications and pharmacological interventions for managing dyslipidemias.
  • Focus is placed on novel therapeutic approaches aimed at elevating circulating HDL levels to mitigate cardiovascular risk.

Impact:

  • Provides a comprehensive overview of HDL's role in preventing atherosclerosis.
  • Informs clinical practice regarding the management of dyslipidemias and cardiovascular risk.
  • Guides future research into HDL-targeting therapies for improved cardiovascular outcomes.

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