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Updated: May 9, 2026

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

Published on: January 20, 2023

Posttraumatic stress disorder and anesthesia emergence.

Donnamarie Lovestrand¹, Steven Phipps, Steven Lovestrand

¹Postanesthesia Care Unit, Bayne-Jones Army Community Hospital, Fort Polk, Louisiana, USA. Donnamarie.d.lovestrand.civ@mail.mil

|August 9, 2013

Summary

Emergence agitation in patients with posttraumatic stress disorder (PTSD) requires specialized care. Evidence-based interventions, not traditional methods, improve patient outcomes in the postanesthesia period.

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Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

Published on: January 20, 2023

Area of Science:

Anesthesiology
Psychiatry
Military Medicine

Background:

Emergence agitation and delirium are common postanesthesia complications.
Combat-related posttraumatic stress disorder (PTSD) can exacerbate emergence agitation.
Limited research exists on managing emergence agitation in PTSD patients.

Observation:

Two case studies illustrate outcomes with traditional versus evidence-driven interventions.
Traditional reorientation methods were ineffective for PTSD patients.
Evidence-based strategies demonstrated improved patient outcomes.

Findings:

Best practices include early identification of at-risk patients.
Minimally stimulating environments and intraoperative sympatholytic therapy are crucial.
Patient and staff education enhances care quality.

Implications:

Military medical professionals can lead research in this area.
Improved management protocols can enhance patient care and outcomes.
Further research is needed to strengthen evidence-based guidelines.