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Updated: May 9, 2026

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

Novel role of microRNAs in prostate cancer

Jun-jie Yu1, Shu-jie Xia

  • 1Department of Urology, First People's Hospital, Shanghai Jiao Tong University, Shanghai 200080, China.

Chinese Medical Journal
|August 9, 2013
PubMed
Abstract

Insights

MicroRNAs are key regulators in prostate cancer, influencing processes like cell growth and spread. Further research is needed to fully understand their role in prostate cancer development.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biomarkers

Background:

  • Prostate cancer remains a significant health concern globally.
  • MicroRNAs (miRNAs) have emerged as critical regulators in various cancers.
  • Understanding novel miRNA biomarkers is crucial for advancing prostate cancer diagnostics and therapeutics.

Purpose of the Study:

  • To review and discuss the emerging role of microRNAs as novel biomarkers in prostate cancer.
  • To highlight the involvement of miRNAs in key prostate cancer biological processes.

Main Methods:

  • A comprehensive literature search was conducted using PubMed.
  • Articles published in English between 2004 and 2012 were included.
  • Focus was placed on original research detailing the novel functions of miRNAs in prostate cancer.

Main Results:

  • MicroRNAs significantly impact prostate cancer through regulation of cell differentiation, proliferation, and apoptosis.
  • miRNAs are implicated in epithelial-mesenchymal transition (EMT), cancer stem cells (CSCs), and drug sensitivity.
  • Associations were found between miRNAs and cancer microenvironment, metabolism, androgen independence, and diagnostic prediction.

Conclusions:

  • MicroRNAs are integral to diverse aspects of prostate cancer biology.
  • The precise role of miRNAs in prostate cancer initiation and progression warrants extensive further investigation.

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