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Published on: June 28, 2021
Urinary trypsinogen-2 for diagnosing acute pancreatitis: a meta-analysis
Tao Jin1, Wei Huang, Kun Jiang
1Sichuan Provincial Pancreatitis Center, Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, China. xiaqing@medmail.com.cn
Urinary trypsinogen-2 (UT-2) shows promise as a diagnostic marker for acute pancreatitis and post-ERCP pancreatitis. Its diagnostic value is comparable to serum amylase, though less than serum lipase.
Area of Science:
- Gastroenterology
- Clinical Diagnostics
- Biomarker Research
Background:
- Serum amylase and lipase are standard markers for acute pancreatitis diagnosis.
- The clinical utility of urinary trypsinogen-2 (UT-2) for acute pancreatitis and post-ERCP pancreatitis requires systematic evaluation.
Purpose of the Study:
- To systematically assess the diagnostic value of UT-2 for acute pancreatitis.
- To evaluate UT-2's effectiveness in diagnosing post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis.
Main Methods:
- A meta-analysis of 18 clinical trials was conducted.
- Searched PubMed, Embase, and Web of Science for relevant studies.
- Calculated pooled sensitivity, specificity, diagnostic odds ratios (DORs), and area under the curve (AUC).
Main Results:
- UT-2 demonstrated pooled sensitivity of 80% and specificity of 92% for acute pancreatitis (AUC=0.96).
- For post-ERCP pancreatitis, UT-2 showed pooled sensitivity of 86% and specificity of 94% (AUC=0.92).
- UT-2's diagnostic performance was comparable to serum amylase but inferior to serum lipase.
Conclusions:
- UT-2 shows potential as a rapid diagnostic test for post-ERCP pancreatitis.
- UT-2 may also aid in diagnosing acute pancreatitis, though further research is needed.
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Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute Pancreatitis II: Clinical Manifestations and Management
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Assessment: