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Hypoglycemia and Glucagon

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Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...

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Updated: May 9, 2026

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice

Published on: November 16, 2011

[Adrenal carcinoma induced hypoglycemia].

Jimena Soutelo¹, Melina Saban, Florencia Borghi Torzillo

¹Servicio de Endocrinología, Complejo Médico Churruca-Visca, Buenos Aires, Argentina. jimesoutelo@arnet.com.ar

|August 9, 2013

Summary

A rare adrenal carcinoma case presented with severe hypoglycemia due to excess androgens. Surgical removal normalized blood glucose and hormone levels, resolving symptoms in this patient.

Keywords:

adrenal carcinoma hypoglycemia insulin-like growth factor II (IGFII)

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Last Updated: May 9, 2026

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice

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Improving IV Insulin Administration in a Community Hospital

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Published on: June 11, 2012

Area of Science:

Endocrinology
Oncology
Case Report

Background:

Adrenal carcinoma is a rare cancer with a poor prognosis.
Clinical manifestations typically arise from hormone overproduction.
Symptomatic hypoglycemia is an exceptionally rare presentation.

Observation:

A 37-year-old woman presented with severe hypoglycemia, hypertension, hypokalemia, and amenorrhea.
Laboratory tests revealed hypoglycemia with low insulin and tumor-level androgen levels.
Abdominal CT identified a heterogeneous retroperitoneal mass with significant contrast enhancement.

Findings:

Surgical resection of the retroperitoneal mass was performed.
The patient experienced an uncomplicated recovery post-surgery.
Normalization of blood glucose, potassium levels, and blood pressure was observed.

Implications:

This case highlights an unusual presentation of adrenal carcinoma.
Successful surgical management can lead to complete symptom resolution.
Further research into rare endocrine manifestations of adrenal tumors is warranted.