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Related Experiment Video

Updated: May 9, 2026

Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches

Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches

Published on: May 6, 2015

Nonreplicating vectors in HIV vaccines.

Jennifer A Johnson¹, Dan H Barouch, Lindsay R Baden

¹Division of Infectious Diseases, Brigham and Women's Hospital, Beth Israel Deaconess Medical Center cHarvard Medical School, Boston, Massachusetts 02115, USA. jjohnson30@partners.org

Current Opinion in HIV and AIDS

|August 9, 2013

Summary

Nonreplicating viral vectors show promise for HIV vaccines, building on canarypox success. While some adenovirus vectors failed, others show potential, alongside novel vectors like rhabdoviruses and alphaviruses.

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Area of Science:

Virology
Immunology
Vaccinology

Background:

Nonreplicating viral vectors are extensively studied for HIV vaccine development.
Preclinical and clinical efficacy trials have evaluated various vector platforms.

Purpose of the Study:

To review the broad spectrum of nonreplicating viral vectors for HIV vaccine candidates.
To discuss promising candidates and their potential in ongoing and future studies.

Main Methods:

Review of preclinical studies and clinical efficacy trials.
Analysis of safety, immunogenicity, and efficacy data for different viral vectors.

Main Results:

The RV144 trial demonstrated success with a canarypox virus-based regimen.
Adenovirus-5 (Ad5)-based regimens failed in multiple clinical trials (Step, Phambili, HVTN 505).

Conclusions:

Nonreplicating viral vectors offer an attractive safety profile and immunogenicity for HIV vaccine development.
Orthopoxvirus-based vaccines (including vaccinia) and alternative adenovirus serotypes show future promise.
Rhabdoviruses, alphaviruses, and nonhuman adenoviruses represent additional exploration avenues.