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Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

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Five Arab children with glucose-galactose malabsorption.

Asaad Assiri¹, Anjum Saeed, Abdulrehman Alnimri

¹Department of Pediatrics, Faculty of Medicine, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia. prof-asaad@hotmail.com

Paediatrics and International Child Health

|August 9, 2013

Summary

Glucose-galactose malabsorption (GGM) is a rare condition causing chronic diarrhea in infants. Early diagnosis and fructose-based formulas are crucial for managing this glucose malabsorption disorder.

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Area of Science:

Pediatrics
Gastroenterology
Human Genetics

Background:

Glucose-galactose malabsorption (GGM) is an inherited disorder affecting nutrient absorption.
It presents in infancy with severe gastrointestinal symptoms.

Observation:

Five infants with GGM from diverse origins were studied.
All infants exhibited chronic diarrhea, failure to thrive, and reducing substances in stools.
Sugar chromatography confirmed glucose and galactose malabsorption, with normal small bowel biopsies.

Findings:

Complications included dehydration, hypernatremia, gangrene requiring amputation, and nephrolithiasis.
All infants showed significant improvement with fructose-based formulas.
This highlights the critical role of dietary management.

Implications:

GGM should be considered in the differential diagnosis of infant chronic diarrhea.
Prompt diagnosis and appropriate management with fructose-based diets can prevent severe complications.
Genetic counseling may be beneficial for affected families.