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Related Experiment Video

Updated: May 9, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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Low fetuin-A level in migraine: a case-control study.

Mehmet Halis Tanriverdi1, Sefer Varol, Adalet Arikanoglu

  • 1Department of Family Medicine, Faculty of Medicine, School of Medicine, Dicle University, 21280, Diyarbakir, Turkey, dr.mht@hotmail.com.

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
|August 9, 2013
PubMed
Summary

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Migraine patients show lower levels of fetuin-A, matrix metalloproteinase-3 (MMP-3), and MMP-9 compared to healthy individuals. Low fetuin-A may play a role in migraine pathogenesis.

Area of Science:

  • Neurology
  • Biochemistry
  • Metabolic Disorders

Background:

  • Migraine pathogenesis involves trigeminovascular system alterations and neurovascular inflammation.
  • Migraine is linked to an increased risk of metabolic disorders.
  • Specific biomarkers like matrix metalloproteinases (MMP), fetuin-A, ghrelin, and omentin are implicated in metabolic and inflammatory processes.

Purpose of the Study:

  • To investigate serum levels of MMPs, fetuin-A, ghrelin, and omentin in migraine patients.
  • To examine the relationship between these biomarkers and migraine subtypes or attack frequency.

Main Methods:

  • Enrolled 49 migraine patients and 30 healthy controls, diagnosed using the International Classification of Headache Disorders-II criteria.
  • Measured serum levels of MMP-9, MMP-3, ghrelin, omentin, and fetuin-A using ELISA.

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  • Analyzed correlations between biomarker levels and clinical parameters like age, disease duration, and attack frequency.

    • Main Results:

    • Migraine patients exhibited significantly lower serum levels of fetuin-A, MMP-9, and MMP-3 compared to controls (p < 0.05).
    • No significant differences were observed in omentin and ghrelin levels between groups (p > 0.05).
    • In migraine patients, serum fetuin-A positively correlated with MMP-9 and negatively with MMP-3; no biomarkers correlated with age, disease duration, or attack frequency.

    Conclusions:

    • Migraine patients demonstrate reduced levels of fetuin-A, MMP-3, and MMP-9.
    • Lower fetuin-A levels in migraine patients may contribute to the condition's pathogenesis.
    • Further research is needed to elucidate the impact of these findings on migraine's pathogenesis, characteristics, and treatment.