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Updated: May 9, 2026
Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Antitumor activity of new enantiopure pybox-ruthenium complexes
Estefania Menéndez-Pedregal1, Josefina Díez, Ángel Manteca
1Departamento de Química Orgánica e Inorgánica, Instituto de Química Organometálica "Enrique Moles" (Unidad Asociada al C.S.I.C.). Universidad de Oviedo, 33006 Oviedo, Principado de Asturias, Spain. elb@uniovi.es.
Abstract:
New ruthenium complexes containing enantiopure 2,6-bis[4'(R)-phenyloxazolin-2'-il-pyridine] ((R,R)-Ph-pybox), 2,6-bis[4'(S)-isopropyloxazolin-2'-il-pyridine] ((S,S)-(i)Pr-pybox) or 2,6-bis[4'(R)-isopropyloxazolin-2'-il-pyridine] ((R,R)-(i)Pr-pybox) and water soluble 1,3,5-triaza-7-phosphaadamantane (PTA) or N-substituted PTA phosphanes have been synthesized in high yields and fully characterized. The interactions of these compounds with plasmidic DNA and their cytotoxic activity against the human cervical cancer HeLa cell line are reported, pointing out for the first time the different behaviour of ruthenium enantiomers affecting the cell cycle in HeLa tumor cells.
