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Related Concept Videos

Aneurysm I: Introduction01:30

Aneurysm I: Introduction

An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...

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Related Experiment Video

Updated: May 9, 2026

Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion
05:31

Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion

Published on: May 16, 2025

[Progress in genetic study of aortic dissection].

Yong-sheng Li1, Wei-guo Fu, Zhi-hui Dong

  • 1Department of Vascular Surgery, Zhongshan Hospital, Institute of Vascular Surgery, Fudan University, Shanghai 200032, P. R. China. fu.weiguo@zs-hospital.sh.cn.

Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics
|August 9, 2013
PubMed
Summary
This summary is machine-generated.

Genetic research reveals aortic dissection is a complex, multi-gene disorder. Understanding these genetic factors is key to uncovering the disease

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Related Experiment Videos

Last Updated: May 9, 2026

Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion
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Novel and Innovative Hybrid Technique for Type A Aortic Dissection
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Novel and Innovative Hybrid Technique for Type A Aortic Dissection

Published on: March 28, 2025

Area of Science:

  • Genetics
  • Cardiovascular Disease Research
  • Molecular Biology

Context:

  • Aortic dissection etiology remains incompletely understood.
  • Genetic predisposition plays a role in cardiovascular diseases.
  • Previous studies have identified potential genetic links.

Purpose:

  • To investigate the genetic underpinnings of aortic dissection.
  • To identify specific gene mutations associated with the disease.
  • To explore the role of genetic factors in aortic dissection pathogenesis.

Summary:

  • Genetic studies, including microarray screening and polymorphism testing, have identified multiple genes implicated in aortic dissection.
  • Aortic dissection is characterized as a multi-gene disorder, suggesting synergistic gene interactions.
  • The findings highlight the contribution of genetic changes and malfunctions to disease development.

Impact:

  • Provides crucial insights into the etiology and natural history of aortic dissection.
  • Suggests potential targets for future diagnostic and therapeutic strategies.
  • Enhances understanding of the genetic basis of complex cardiovascular conditions.