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[Association between 1019C/T polymorphism of Connexin 37 gene and restenosis after coronary stenting]
Ying Yang1, Su-xia Guo, Zhen-yu Yang
1Department of Cardiology, Affiliated People's Hospital of Nanjing Medical University in Wuxi and People's Hospital of Wuxi, Wuxi, Jiangsu 214023, P. R. China. guo7771812@163.com.
Insights
The C allele of the Connexin 37 (CX37) 1019C/T gene polymorphism increases the risk of coronary artery disease (CAD) and restenosis after percutaneous coronary intervention (PCI). This association was particularly significant in male patients.
Area of Science:
- Genetics
- Cardiovascular Medicine
- Molecular Biology
Background:
- Coronary artery disease (CAD) remains a leading cause of mortality worldwide.
- Percutaneous coronary intervention (PCI) is a common revascularization procedure for CAD.
- Restenosis after PCI is a significant clinical challenge, necessitating research into its underlying genetic factors.
Purpose of the Study:
- To investigate the association between the 1019C/T polymorphism of the Connexin 37 (CX37) gene and the susceptibility to restenosis following PCI.
- To evaluate the role of this polymorphism in the development of CAD and post-PCI restenosis in ethnic Han Chinese patients.
Main Methods:
- A case-control study involving 532 patients who underwent PCI and 501 healthy controls.
- Patients were categorized into in-stent restenosis (ISR) and no-in-stent restenosis (NISR) groups based on coronary angiography.
- Genotyping for the CX37 1019C/T polymorphism was performed using DNA sequencing.
Main Results:
- The frequency of the CX37 C allele and C carriers (CC+TC genotypes) was significantly higher in CAD patients compared to healthy controls.
- Carriers of the C allele had an increased risk of developing CAD.
- The frequency of the C allele and C carriers was significantly higher in the ISR group compared to the NISR group, indicating an increased risk of restenosis, particularly in male patients.
Conclusions:
- The C allele of the CX37 1019C/T polymorphism is associated with increased susceptibility to CAD.
- This polymorphism is also linked to a higher risk of restenosis after coronary stenting, especially in male patients.
- The findings suggest CX37 genotype may be a predictive marker for CAD and post-PCI restenosis in the studied population.
Objective:
To assess the association between 1019C/T polymorphism of Connexin 37 (CX37) gene and susceptibility to restenosis after percutaneous coronary intervention (PCI) in ethnic Han Chinese patients from Wuxi.
Methods:
Five hundred and thirty-two patients with coronary artery disease (CAD) who had undergone PCI underwent coronary angiography (CAG) in 3 months, and were divided into in stent restenosis (ISR) group (n=67) and no instent restenosis (NISR) group (n=465). Five hundred and one healthy individuals have served as the control group. All cases were genotyped with DNA sequencing.
Results:
Compared with healthy controls, the frequency of CX37 C allele was higher in CAD patients (57.05% vs. 41.32%, P< 0.01). The frequency of C carries (CC+TC) was 79.32% in CAD patients, against 65.47% in healthy controls (P<0.01). The risk for CAD was significantly increased in carriers of C allele (CC+TC) compared with TT homozygotes (OR=2.03, 95% CI: 1.53-2.80). Stratified analysis has indicated a significant difference in the frequency of C allele carriers between both male and female CAD patients and healthy controls (79.63% vs. 72.45%, P=0.02; 78.00% vs. 51.50%, P< 0.01). For both genders, carriers of C allele had a higher risk for CAD compared with TT homozygotes (males: OR=1.48, 95% CI: 1.06-2.09; females: OR=3.34, 95% CI: 1.90-5.86). Compared with NISR group, the frequency of CX37 C allele and C carries (CC+TC) were significantly higher in ISR group (72.39% vs. 54.84%, P< 0.01; 89.55% vs. 77.85%, P=0.027). Compared with TT homozygotes, the risk for restenosis has significantly increased in carriers of C allele (CC+TC) (OR=2.44, 95% CI: 1.08-5.50). Stratified analysis also suggested that the frequency of C carriers was significantly higher in male ISR group compared with male NISR group (92. 86% vs. 77.66%, P=0.008). The risk for restenosis has increased by nearly four fold in carriers of C allele (CC+TC) compared with TT homozygotes (95% CI: 1.32-10.64). However, for female patients, no significant difference was detected in the ISR risk between carriers of CC+TC type and TT homozygotes (P=0.655).
Conclusion:
The C allele of 1019C/T polymorphism in the CX37 gene is associated with susceptibility to CAD as well as restenosis after coronary stenting in male patients from Wuxi.
