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Updated: May 9, 2026

Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection

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Published on: February 1, 2022

Graphene-Ruthenium(II) complex composites for sensitive ECL immunosensors.

Fang-Nan Xiao¹, Min Wang, Feng-Bin Wang

¹State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, China.

Small (Weinheim an Der Bergstrasse, Germany)

|August 9, 2013

Summary

A novel graphene-based nanocomposite enhances electrochemiluminescence (ECL) for sensitive cancer biomarker detection. This solid-state immunosensor offers a promising tool for early disease diagnosis and biomolecular detection.

Keywords:

ECL immunosensor PTCA graphene nanocomposites ruthenium(II) complex

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The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes

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The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes

The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphos^Ph Complexes

Published on: April 10, 2015

Area of Science:

Materials Science
Analytical Chemistry
Biotechnology

Background:

Non-covalent modification of graphene preserves its structure and electronic properties while enhancing chemical characteristics.
Developing sensitive and stable biosensors is crucial for early disease diagnosis.

Purpose of the Study:

To fabricate a novel solid-state electrochemiluminescent (ECL) immunosensor for sensitive detection of α-fetoprotein (AFP).
To create highly luminescent and electrochemically active graphene-based nanocomposites for improved sensor performance.

Main Methods:

One-pot synthesis of ruthenium(II) complex/3,4,9,10-perylenetetracarboxylic acid (PTCA)/graphene (Ru-PTCA/G) nanocomposites.
Fabrication of an ECL immunosensor using Ru-PTCA/G modified electrodes and anti-AFP for AFP detection via steric hindrance.

Main Results:

The Ru-PTCA/G nanocomposites exhibited significantly enhanced luminescence quantum efficiency (approx. 21 times higher than adsorbed derivatives).
The solid-state ECL sensor demonstrated high stability.
The immunosensor achieved a sensitive response to AFP in a linear range of 5 pg·mL⁻¹ -10 ng·mL⁻¹ with a low detection limit of 0.2 pg·mL⁻¹.

Conclusions:

The developed Ru-PTCA/G nanocomposites are effective for biomolecular immobilization and sensor fabrication.
This approach offers a promising technique for sensitive and stable biomolecular detection, particularly for cancer biomarkers like AFP.