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Related Experiment Video

Updated: May 9, 2026

Early Unguided Human Brain Organoid Neurovascular Niche Modeling into the Permissive Chick Embryo Chorioallantoic Membrane

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Cup of Joe: a brain development "no"?

Zeeba D Kabir¹, Deirdre M McCarthy, Pradeep G Bhide

¹Department of Pediatrics, Division of Pediatric Neurology, Weill Cornell Medical College, New York, NY 10021, USA.

Science Translational Medicine

|August 9, 2013

Summary

Pregnant mice exposed to caffeine, an adenosine receptor antagonist, experienced delayed neural development in offspring. This highlights potential risks of caffeine during pregnancy on fetal brain development.

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Short-Term Free-Floating Slice Cultures from the Adult Human Brain

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Published on: November 5, 2019

Area of Science:

Neuroscience
Developmental Biology
Pharmacology

Background:

Adenosine receptors play a crucial role in brain development.
Caffeine is a widely consumed adenosine receptor antagonist.
Disruptions in neuronal migration are linked to developmental brain abnormalities.

Purpose of the Study:

To investigate the effects of maternal exposure to adenosine receptor antagonists on cortical neuron migration.
To examine the impact of caffeine on the brain development of mouse offspring.

Main Methods:

Pregnant mice were treated with adenosine receptor antagonists, including caffeine.
The migration patterns of cortical gamma-aminobutyric acid (GABA) neurons in offspring were analyzed.
Brain development in the offspring was assessed.

Main Results:

Maternal administration of adenosine receptor antagonists, such as caffeine, led to delayed migration of cortical GABA neurons in offspring.
Altered brain development was observed in the mouse offspring exposed prenatally to these antagonists.

Conclusions:

Maternal caffeine consumption may interfere with normal fetal cortical development.
Adenosine receptor signaling is critical for timely neuronal migration and overall brain development.