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Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Seizures: Classification01:13

Seizures: Classification

Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:

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Related Experiment Video

Updated: May 9, 2026

Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex
09:00

Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex

Published on: April 15, 2015

Posterior cingulate epilepsy: clinical and neurophysiological analysis.

Rei Enatsu1, Juan Bulacio, Dileep R Nair

  • 1Epilepsy Center, Cleveland Clinic Foundation, , Cleveland, Ohio, USA.

Journal of Neurology, Neurosurgery, and Psychiatry
|August 9, 2013
PubMed
Summary

Posterior cingulate epilepsy (PCE) is rare and challenging to diagnose. This study characterizes its clinical and neurophysiological features, revealing that seizure spread patterns influence semiology and network involvement.

Keywords:
Brain MappingEpilepsyNeurophysiologyNeurosurgery

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Area of Science:

  • Neurology
  • Epileptology
  • Neurophysiology

Background:

  • Posterior cingulate epilepsy (PCE) presents diagnostic challenges due to deep, silent seizure onset zones.
  • PCE is rare, necessitating further characterization for improved presurgical evaluation and surgical strategies.

Purpose of the Study:

  • To elucidate the clinical and neurophysiological characteristics of posterior cingulate epilepsy.
  • To enhance understanding of PCE for better interpretation of presurgical evaluations and surgical planning.

Main Methods:

  • Retrospective analysis of seven intractable PCE patients.
  • Stereotactic EEG (SEEG) for ictal onset identification, scalp EEG, and cortico-cortical evoked potential (CCEP) analysis.
  • Evaluation of clinical semiology, EEG findings, and CCEP data.

Main Results:

  • Scalp EEG classifications varied widely. Motor manifestations occurred in three patients with spread to frontal and parietal areas.
  • Dialeptic or automotor seizures were observed in four patients with spread to temporal or inferior parietal lobule (IPL) areas.
  • CCEP indicated electrophysiological connections from the posterior cingulate gyrus to parietal, temporal, occipital, and frontal regions.

Conclusions:

  • The seizure spread patterns in PCE dictate the resulting semiology, ranging from motor to dialeptic/automotor seizures.
  • Understanding these spread patterns is crucial for defining the involved network originating from the posterior cingulate gyrus.
  • This characterization aids in refining diagnostic and therapeutic approaches for posterior cingulate epilepsy.