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Relation between Delayed Superfluous Insulin Secretion during An Oral Glucose Tolerance Test and Metabolic Disorders

Hidetoshi Sato1, Toru Kikuchi, Waka Harada

  • 1Department of Pediatrics, Shonai Hospital, Tsuruoka, Japan ; Division of Pediatrics, Department of Homeostatic Regulation and Development, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Clinical Pediatric Endocrinology : Case Reports and Clinical Investigations : Official Journal of the Japanese Society for Pediatric Endocrinology
|August 9, 2013
PubMed

Insights

Delayed insulin secretion in obese children is linked to metabolic disorders. This finding highlights the need for obesity prevention and better management in pediatric populations to avoid a cycle of hyperinsulinemia.

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Syndrome
  • Obesity Research

Background:

  • Childhood obesity is a growing concern with potential long-term health consequences.
  • Metabolic disorders, including impaired liver function and dyslipidemia, are increasingly prevalent in obese children.
  • Understanding the relationship between insulin response and metabolic health in obese youth is crucial.

Purpose of the Study:

  • To investigate the association between postprandial hyperinsulinemia and metabolic disorders in obese Japanese children.
  • To analyze insulin and C-peptide secretion patterns during an oral glucose tolerance test (OGTT) in relation to metabolic health status.

Main Methods:

  • Twenty-eight obese Japanese children were categorized into four groups based on liver function and dyslipidemia status.
  • An oral glucose tolerance test (OGTT) was performed, measuring plasma glucose (PG), serum immunoreactive insulin (IRI), and serum C-peptide (CPR).
  • Insulin and C-peptide secretion profiles were analyzed across different groups.

Main Results:

  • Obese children exhibited delayed insulin and C-peptide secretion during the OGTT compared to healthy references.
  • Distinct insulin secretion patterns were observed, with delayed peaks (60-120 min) and prolonged elevated levels in groups with metabolic disorders.
  • Group D (impaired liver function and dyslipidemia) showed the most delayed and sustained insulin response.

Conclusions:

  • Delayed insulin secretion during OGTT is associated with metabolic disorders in obese Japanese children.
  • These findings suggest a potential vicious cycle of postprandial hyperinsulinemia and metabolic disturbances.
  • Emphasizes the importance of obesity prevention and improved management strategies in childhood.

Keywords:
delayed superfluous insulin secretionobese childrenoral glucose tolerance testpostprandial hyperinsulinemia

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