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Related Concept Videos

Chronic Obstructive Pulmonary Disease01:24

Chronic Obstructive Pulmonary Disease

COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
Chronic Obstructive Pulmonary Disease-V: Management01:29

Chronic Obstructive Pulmonary Disease-V: Management

Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation

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Related Experiment Video

Updated: May 9, 2026

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease
07:10

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease

Published on: August 24, 2019

Removing extra CO2 in COPD patients.

Laura W Lund1, William J Federspiel

  • 1ALung Technologies, Inc, 2500 Jane Street, Suite 1, Pittsburgh, PA 15203.

Current Respiratory Care Reports
|August 9, 2013
PubMed
Summary
This summary is machine-generated.

Extracorporeal carbon dioxide removal (ECCO2R) shows promise for managing acute hypercapnic respiratory failure in severe chronic obstructive pulmonary disease (COPD) exacerbations, offering an alternative when noninvasive ventilation fails. This approach focuses on partial CO2 removal to improve patient outcomes.

Keywords:
Active mixingAcute exacerbationAcute hypercapnic respiratory failureChronic obstructive pulmonary diseaseExtracorporeal carbon dioxide removalExtracorporeal gas exchangeExtracorporeal membrane oxygenationHemolungHypercapniaHypercarbiaMechanical ventilationNoninvasive ventilationNovalungRespiratory dialysis

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Alternative Therapy for Acute Exacerbation of Chronic Obstructive Pulmonary Disease: Moving Cupping Along Meridians
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Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method
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Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method

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Alternative Therapy for Acute Exacerbation of Chronic Obstructive Pulmonary Disease: Moving Cupping Along Meridians
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Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method
08:44

Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method

Published on: February 2, 2024

Area of Science:

  • Pulmonary Medicine
  • Critical Care Medicine
  • Cardiopulmonary Support Technologies

Background:

  • Noninvasive positive pressure ventilation (NPPV) improves outcomes for acute respiratory failure in chronic obstructive pulmonary disease (COPD) exacerbations compared to invasive mechanical ventilation.
  • Refractory hypercapnia and hypercapnic acidosis limit the effectiveness of NPPV in some COPD patients.
  • Extracorporeal gas exchange technologies have advanced, with a focus on partial extracorporeal carbon dioxide removal (ECCO2R) for enhanced safety and simplicity.

Purpose of the Study:

  • To review recent literature (last year) on the application of ECCO2R for acute hypercapnic respiratory failure in COPD exacerbations.
  • To evaluate the potential of ECCO2R as a therapeutic option for COPD patients who do not respond adequately to noninvasive ventilation.

Main Methods:

  • Literature review focusing on studies published within the last year.
  • Analysis of research investigating the use of partial extracorporeal carbon dioxide removal (ECCO2R) systems.
  • Focus on clinical data related to acute hypercapnic respiratory failure during COPD exacerbations.

Main Results:

  • ECCO2R systems are being developed for safer and simpler partial extracorporeal carbon dioxide removal.
  • While studied in ARDS, ECCO2R's efficacy in COPD exacerbations with acute hypercapnic respiratory failure is a recent area of investigation.
  • Emerging data suggests potential benefits of ECCO2R in this specific patient population.

Conclusions:

  • ECCO2R represents a developing therapeutic strategy for acute hypercapnic respiratory failure in severe COPD exacerbations.
  • Further research is needed to fully establish the role and optimal use of ECCO2R in this clinical setting.
  • Partial CO2 removal via ECCO2R may offer a viable alternative for patients refractory to conventional noninvasive ventilation.