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Primary total knee arthroplasty in patients with Parkinson's disease: analysis of outcomes

Craig G Tinning1, Lynda A Cochrane, Brian R Singer

  • 1Department of Orthopaedic and Trauma Surgery, Ninewells Hospital, Dundee, UK. c.tinning@yahoo.co.uk

Acta Orthopaedica Belgica
|August 10, 2013
PubMed

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Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
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Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of which...