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Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Related Experiment Video

Updated: May 9, 2026

Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery
10:38

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Published on: January 15, 2018

Surface functionalized gold nanoparticles for drug delivery.

Jinping Cheng1, Yan-Juan Gu, Shuk Han Cheng

  • 1State Key Lab of Estuarine and Coastal Research, East China Normal University, Shanghai 200062, China.

Journal of Biomedical Nanotechnology
|August 10, 2013
PubMed
Summary
This summary is machine-generated.

Gold nanoparticles show promise as biocompatible drug delivery vehicles. Functionalized gold nanoparticles overcome multidrug resistance in cancer cells by enhancing drug entry and cytotoxicity.

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Area of Science:

  • Nanotechnology
  • Biomedical Engineering
  • Pharmacology

Background:

  • Gold nanoparticles (AuNPs) are explored for cancer therapy and diagnostics.
  • Their biocompatibility and size make them suitable for drug delivery.
  • Folic acid coating enhances targeting and cellular uptake.

Purpose of the Study:

  • To develop and evaluate folic acid-coated gold nanoparticles as a drug delivery system.
  • To assess the efficacy of doxorubicin-conjugated gold nanoparticles in overcoming multidrug resistance.
  • To investigate the cellular uptake and cytotoxicity of these nanoconjugates.

Main Methods:

  • Synthesis of folic acid-coated gold nanoparticles conjugated with FITC.
  • Preparation of doxorubicin-conjugated gold nanoparticles (Au-SMCC-DOX) using a PEG spacer and SMCC linker.
  • Confocal microscopy and bright-field imaging for cellular uptake studies.
  • Cytotoxicity assays on human fibroblasts and multidrug-resistant cancer cells (hepG2-R).

Main Results:

  • Folic acid-coated AuNPs accumulated in the cytoplasm of fibroblasts with no observed cytotoxicity.
  • Au-SMCC-DOX nanoconjugates demonstrated efficient cellular entry and enhanced cytotoxicity in cancer cells.
  • Enhanced drug accumulation and retention of Au-SMCC-DOX compared to free doxorubicin in hepG2-R cells.
  • Cytoplasmic accumulation profile observed for nanoconjugates.

Conclusions:

  • Gold nanoparticles are promising, biocompatible drug delivery vehicles.
  • Functionalized AuNPs effectively overcome multidrug resistance in cancer.
  • This approach holds potential for improved chemotherapy strategies.