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A sophisticated multi-step secretion mechanism: how the type 3 secretion system is regulated
Nicola Barison1, Rashmi Gupta, Michael Kolbe
1Max-Planck-Institute for Infection Biology, Cellular Microbiology, Charitéplatz 1, 10117, Berlin, Germany.
Cellular Microbiology
|August 10, 2013
Summary
Gram-negative pathogens use type 3 secretion systems (T3SSs) to infect hosts. This review details T3SS regulation mechanisms and proposes an updated secretion model integrating recent data.
Area of Science:
- Microbiology
- Molecular Biology
- Pathogenesis
Background:
- Gram-negative pathogens employ type 3 secretion systems (T3SSs) for host cell invasion.
- T3SSs are complex molecular machines that translocate bacterial effector proteins into host cells.
Purpose of the Study:
- To review the regulatory mechanisms controlling T3SS activity.
- To present an updated model of T3SS secretion.
Main Methods:
- Literature review of T3SS regulation.
- Integration of recent structural and functional data.
Main Results:
- T3SS regulation involves multi-step strategies.
- Diverse mechanisms control effector protein secretion in response to stimuli.
Conclusions:
- T3SS regulation is a complex, multi-stage process.
- An updated model provides a comprehensive view of T3SS secretion stages.
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