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Merkel Cell Polyomavirus Infection and Detection

Published on: February 7, 2019

Prolonged polyarthralgia in a German traveller with Mayaro virus infection without inflammatory correlates

Christian Theilacker, Jürgen Held, Ludger Allering

    BMC Infectious Diseases
    |August 10, 2013
    PubMed
    Abstract

    Insights

    Mayaro virus, causing dengue-like illness with severe joint pain, is spreading globally. Early recognition is crucial for travelers and clinicians, as this rare infection can be misdiagnosed.

    Area of Science:

    • Medical Entomology
    • Tropical Medicine
    • Virology

    Background:

    • Mayaro virus (MAYV) is endemic in South America, causing febrile illness and severe polyarthralgias.
    • Outbreaks are sporadic, and MAYV infection can be misdiagnosed as dengue fever outside endemic areas.
    • International travelers are at risk, necessitating awareness among infectious disease specialists.

    Observation:

    • A case of imported Mayaro virus infection in Germany is reported.
    • A young woman presented with fever, myalgia, rash, and prolonged polyarthralgias after traveling in Bolivia.
    • Diagnosis was confirmed by serological detection of Mayaro virus-specific IgM and IgG antibodies.

    Findings:

    • The patient experienced severe polyarthralgias lasting five months, managed with NSAIDs.
    • Pro-inflammatory cytokines, except CXCL8/IL-8, were unremarkable during serological testing.
    • This case highlights the potential for Mayaro virus to be imported into non-endemic regions.

    Implications:

    • Increased global travel necessitates awareness of Mayaro virus for accurate diagnosis and patient management.
    • Further understanding of Mayaro virus pathogenesis and host interactions is essential for effective treatment.
    • Disseminating knowledge on rare infectious diseases like Mayaro virus improves clinical outcomes.

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