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Published on: June 12, 2021

Clinical manifestations of Kawasaki disease shock syndrome: a case-control study

Pei-Shin Chen1, Hsin Chi2, Fu-Yuan Huang1

  • 1Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan.

Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi
|August 10, 2013
PubMed

Insights

Kawasaki disease shock syndrome (KDSS) is a severe condition that can be difficult to diagnose. KDSS patients present with more prominent inflammatory markers and a higher risk of coronary artery dilatation compared to typical Kawasaki disease (KD).

Area of Science:

  • Pediatric Cardiology
  • Critical Care Medicine
  • Infectious Diseases

Background:

  • Kawasaki disease shock syndrome (KDSS) is a severe complication of Kawasaki disease (KD).
  • KDSS diagnosis can be challenging due to atypical presentations.
  • Understanding KDSS is crucial for timely intervention and improved outcomes.

Purpose of the Study:

  • To identify clinical presentations, risk factors, and outcomes of children with KDSS.
  • To compare KDSS patients with typical KD patients without shock.

Main Methods:

  • A retrospective case-control study was conducted.
  • Case patients: children hospitalized with KD and hypotension, sepsis, or shock (2001-2011).
  • Control patients: season-matched children with KD and normal blood pressure.

Main Results:

  • Nine KDSS patients and 27 controls were identified.
  • KDSS patients had lower initial KD diagnosis rates (22.2%) and higher coronary artery dilatation risk (77.8%).
  • Risk factors included elevated neutrophils, CRP, and lower platelets; treatments involved aspirin, IVIG, fluids, and vasoactive infusions.

Conclusions:

  • KDSS may present atypically and be misdiagnosed initially.
  • KDSS patients exhibit heightened early inflammatory markers.
  • There is an increased risk of coronary artery dilatation in KDSS patients.
Abstract

Keywords:
ChildrenKawasaki diseaseKawasaki disease shock syndromeRisk factors

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